WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406321
CAS#: 851757-93-2
Description: PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.
MedKoo Cat#: 406321
Name: PF-376304
CAS#: 851757-93-2
Chemical Formula: C17H24N8O3
Exact Mass: 388.19714
Molecular Weight: 388.42426
Elemental Analysis: C, 52.57; H, 6.23; N, 28.85; O, 12.36
PF376304 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: PF376304; PF 376304; PF-376304.
IUPAC/Chemical Name: 4-(cycloheptyloxy)-2-morpholino-N-(2H-tetrazol-5-yl)pyrimidine-5-carboxamide
InChi Key: KTPKFJPJRYZTMP-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H24N8O3/c26-14(19-16-21-23-24-22-16)13-11-18-17(25-7-9-27-10-8-25)20-15(13)28-12-5-3-1-2-4-6-12/h11-12H,1-10H2,(H2,19,21,22,23,24,26)
SMILES Code: O=C(C1=CN=C(N2CCOCC2)N=C1OC3CCCCCC3)NC4=NNN=N4
The following data is based on the product molecular weight 388.42426 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Robertson DG, Datta K, Wells D, Egnash L, Robosky L, Manning M, Rohde C, Reily MD. Metabonomic evaluation of metabolic dysregulation in rats induced by PF376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol. 2007 Dec;20(12):1871-7. Epub 2007 Nov 15. PubMed PMID: 18001061.