PF-376304

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406321

CAS#: 851757-93-2

Description: PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.

Chemical Structure

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PF-376304
CAS# 851757-93-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406321
Name: PF-376304
CAS#: 851757-93-2
Chemical Formula: C17H24N8O3
Exact Mass: 388.19714
Molecular Weight: 388.42426
Elemental Analysis: C, 52.57; H, 6.23; N, 28.85; O, 12.36

Size Price Shipping out time Quantity
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Pricing updated 2021-02-26. Prices are subject to change without notice.

PF376304 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: PF376304; PF 376304; PF-376304.

IUPAC/Chemical Name: 4-(cycloheptyloxy)-2-morpholino-N-(2H-tetrazol-5-yl)pyrimidine-5-carboxamide

InChi Key: KTPKFJPJRYZTMP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H24N8O3/c26-14(19-16-21-23-24-22-16)13-11-18-17(25-7-9-27-10-8-25)20-15(13)28-12-5-3-1-2-4-6-12/h11-12H,1-10H2,(H2,19,21,22,23,24,26)

SMILES Code: O=C(C1=CN=C(N2CCOCC2)N=C1OC3CCCCCC3)NC4=NNN=N4

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition:
0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly.

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 388.42426 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Robertson DG, Datta K, Wells D, Egnash L, Robosky L, Manning M, Rohde C, Reily MD. Metabonomic evaluation of metabolic dysregulation in rats induced by PF376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol. 2007 Dec;20(12):1871-7. Epub 2007 Nov 15. PubMed PMID: 18001061.

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PF-376304



Additional Information