WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406195

CAS#: 391210-00-7

Description: PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

Chemical Structure

CAS# 391210-00-7

Theoretical Analysis

MedKoo Cat#: 406195
Name: PD318088
CAS#: 391210-00-7
Chemical Formula: C16H13BrF3IN2O4
Exact Mass: 559.90555
Molecular Weight: 561.09
Elemental Analysis: C, 34.25; H, 2.34; Br, 14.24; F, 10.16; I, 22.62; N, 4.99; O, 11.41

Price and Availability

Size Price Availability Quantity
1.0mg USD 215.0 2 Weeks
5.0mg USD 450.0 2 Weeks
10.0mg USD 730.0 2 Weeks
25.0mg USD 1170.0 2 Weeks
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Synonym: PD318088; PD 318088; PD318088.

IUPAC/Chemical Name: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide


InChi Code: InChI=1S/C16H13BrF3IN2O4/c17-10-4-9(16(26)23-27-6-8(25)5-24)15(14(20)13(10)19)22-12-2-1-7(21)3-11(12)18/h1-4,8,22,24-25H,5-6H2,(H,23,26)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 561.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Han S, Zhou V, Pan S, Liu Y, Hornsby M, McMullan D, Klock HE, Haugen J, Lesley SA, Gray N, Caldwell J, Gu XJ. Identification of coumarin derivatives as a novel  class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73. Epub 2005 Sep 30. PubMed PMID: 16199156.

Additional Information