WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510236
CAS#: 152121-53-4
Description: PD-169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM. PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
MedKoo Cat#: 510236
Name: PD-169316
CAS#: 152121-53-4
Chemical Formula: C20H13FN4O2
Exact Mass: 360.10225
Molecular Weight: 360.34
Elemental Analysis: C, 66.66; H, 3.64; F, 5.27; N, 15.55; O, 8.88
Synonym: PD-169316; PD 169316; PD169316.
IUPAC/Chemical Name: 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridine
InChi Key: BGIYKDUASORTBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
SMILES Code: O=[N+](C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2)C=C1)[O-]
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 360.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Krishnamoorthy M, Heimburg-Molinaro J, Bargo AM, Nash RJ, Nash RJ. Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. J Biochem. 2009 Feb;145(2):177-84. doi: 10.1093/jb/mvn153. Epub 2008 Nov 14. PubMed PMID: 19010935; PubMed Central PMCID: PMC2879129.
2: Fu Y, O'Connor LM, Shepherd TG, Nachtigal MW. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7. PubMed PMID: 14521923.
