OM-137
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406166

CAS#: 292170-13-9

Description: OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel.


Chemical Structure

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OM-137
CAS# 292170-13-9

Theoretical Analysis

MedKoo Cat#: 406166
Name: OM-137
CAS#: 292170-13-9
Chemical Formula: C13H14N4O3S
Exact Mass: 306.07866
Molecular Weight: 306.34026
Elemental Analysis: C, 50.97; H, 4.61; N, 18.29; O, 15.67; S, 10.47

Price and Availability

Size Price Availability Quantity
5.0mg USD 220.0 2 Weeks
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Synonym: OM-137; OM137; OM 137

IUPAC/Chemical Name: (E)-2-amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methylthiazole-5-carbohydrazide

InChi Key: AMHQGUWEVRTTJB-GIDUJCDVSA-N

InChi Code: InChI=1S/C13H14N4O3S/c1-7-11(21-13(14)16-7)12(19)17-15-6-8-3-4-9(18)10(5-8)20-2/h3-6,18H,1-2H3,(H2,14,16)(H,17,19)/b15-6+

SMILES Code: O=C(C1=C(C)N=C(N)S1)N/N=C/C2=CC=C(O)C(OC)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 306.34026 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3. PubMed PMID: 19190331; PubMed Central PMCID: PMC265523.

OM-137

5.0mg / USD 220.0


Additional Information