WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406166
Description: OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel.
MedKoo Cat#: 406166
Chemical Formula: C13H14N4O3S
Exact Mass: 306.07866
Molecular Weight: 306.34026
Elemental Analysis: C, 50.97; H, 4.61; N, 18.29; O, 15.67; S, 10.47
OM-137, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: OM-137; OM137; OM 137
IUPAC/Chemical Name: (E)-2-amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methylthiazole-5-carbohydrazide
InChi Key: AMHQGUWEVRTTJB-GIDUJCDVSA-N
InChi Code: InChI=1S/C13H14N4O3S/c1-7-11(21-13(14)16-7)12(19)17-15-6-8-3-4-9(18)10(5-8)20-2/h3-6,18H,1-2H3,(H2,14,16)(H,17,19)/b15-6+
SMILES Code: O=C(C1=C(C)N=C(N)S1)N/N=C/C2=CC=C(O)C(OC)=C2
The following data is based on the product molecular weight 306.34026 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3. PubMed PMID: 19190331; PubMed Central PMCID: PMC265523.