WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406140

CAS#: 441061-33-2

Description: OGT2378 is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system.

Price and Availability




OGT2378 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406140
Name: OGT2378
CAS#: 441061-33-2
Chemical Formula: C11H23NO4
Exact Mass: 233.16271
Molecular Weight: 233.3
Elemental Analysis: C, 56.63; H, 9.94; N, 6.00; O, 27.43

Synonym: OGT-2378 ; OGT2378; OGT 2378

IUPAC/Chemical Name: (2S,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol


InChi Code: InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9-,10+,11+/m0/s1

SMILES Code: O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information



1: Aravind A, Sankar MG, Varghese B, Baskaran S. Regioselective reductive cleavage of bis-benzylidene acetal: stereoselective synthesis of anticancer agent OGT2378 and glycosidase inhibitor 1,4-dideoxy-1,4-imino-l-xylitol. J Org Chem. 2009 Apr 3;74(7):2858-61. doi: 10.1021/jo900030p. PubMed PMID: 19278232.