sinbaglustat (OGT2378)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406140

CAS#: 441061-33-2

Description: sinbaglustat (OGT2378) is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system.

Chemical Structure

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sinbaglustat (OGT2378)
CAS# 441061-33-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406140
Name: sinbaglustat (OGT2378)
CAS#: 441061-33-2
Chemical Formula: C11H23NO4
Exact Mass: 233.16271
Molecular Weight: 233.3
Elemental Analysis: C, 56.63; H, 9.94; N, 6.00; O, 27.43

Size Price Shipping out time Quantity
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Pricing updated 2021-02-27. Prices are subject to change without notice.

sinbaglustat (OGT2378) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: OGT-2378 ; OGT2378; OGT 2378; sinbaglustat.

IUPAC/Chemical Name: (2S,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol

InChi Key: HCZQIIVHWYFIPW-UKKRHICBSA-N

InChi Code: InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9-,10+,11+/m0/s1

SMILES Code: O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 233.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Aravind A, Sankar MG, Varghese B, Baskaran S. Regioselective reductive cleavage of bis-benzylidene acetal: stereoselective synthesis of anticancer agent OGT2378 and glycosidase inhibitor 1,4-dideoxy-1,4-imino-l-xylitol. J Org Chem. 2009 Apr 3;74(7):2858-61. doi: 10.1021/jo900030p. PubMed PMID: 19278232.

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sinbaglustat (OGT2378)



Additional Information