WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406140
Description: sinbaglustat (OGT2378) is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system.
MedKoo Cat#: 406140
Name: sinbaglustat (OGT2378)
Chemical Formula: C11H23NO4
Exact Mass: 233.16271
Molecular Weight: 233.3
Elemental Analysis: C, 56.63; H, 9.94; N, 6.00; O, 27.43
sinbaglustat (OGT2378) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: OGT-2378 ; OGT2378; OGT 2378; sinbaglustat.
IUPAC/Chemical Name: (2S,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol
InChi Key: HCZQIIVHWYFIPW-UKKRHICBSA-N
InChi Code: InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9-,10+,11+/m0/s1
SMILES Code: O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O
The following data is based on the product molecular weight 233.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Aravind A, Sankar MG, Varghese B, Baskaran S. Regioselective reductive cleavage of bis-benzylidene acetal: stereoselective synthesis of anticancer agent OGT2378 and glycosidase inhibitor 1,4-dideoxy-1,4-imino-l-xylitol. J Org Chem. 2009 Apr 3;74(7):2858-61. doi: 10.1021/jo900030p. PubMed PMID: 19278232.