WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406140
CAS#: 441061-33-2
Description: sinbaglustat (OGT2378) is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system.
MedKoo Cat#: 406140
Name: sinbaglustat (OGT2378)
CAS#: 441061-33-2
Chemical Formula: C11H23NO4
Exact Mass: 233.16271
Molecular Weight: 233.3
Elemental Analysis: C, 56.63; H, 9.94; N, 6.00; O, 27.43
This product is not in stock, which may be available by custom synthesis.
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Synonym: OGT-2378 ; OGT2378; OGT 2378; sinbaglustat.
IUPAC/Chemical Name: (2S,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol
InChi Key: HCZQIIVHWYFIPW-UKKRHICBSA-N
InChi Code: InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9-,10+,11+/m0/s1
SMILES Code: O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 233.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Aravind A, Sankar MG, Varghese B, Baskaran S. Regioselective reductive cleavage of bis-benzylidene acetal: stereoselective synthesis of anticancer agent OGT2378 and glycosidase inhibitor 1,4-dideoxy-1,4-imino-l-xylitol. J Org Chem. 2009 Apr 3;74(7):2858-61. doi: 10.1021/jo900030p. PubMed PMID: 19278232.
