WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406352
Description: NU6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor; induces cell-cycle arrest at the G2-M phase.
MedKoo Cat#: 406352
Chemical Formula: C23H30N6O2
Exact Mass: 422.24302
Molecular Weight: 422.52
Elemental Analysis: C, 65.38; H, 7.16; N, 19.89; O, 7.57
NU6140, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: NU6140; NU-6140; NU 6140.
IUPAC/Chemical Name: 4-((6-(cyclohexylmethoxy)-1H-purin-2-yl)amino)-N,N-diethylbenzamide
InChi Key: XHEQSRJCJTWWAH-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
SMILES Code: O=C(N(CC)CC)C1=CC=C(NC2=NC3=NC=NC3=C(OCC4CCCCC4)N2)C=C1
The following data is based on the product molecular weight 422.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang LZ, Curtin N, Golding BT, Griffin RJ, Hardcastle IR, Henderson A, Zaffaroni N, Newell DR. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. PubMed PMID: 16170024.