NU6140
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406352

CAS#: 444723-13-1

Description: NU6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor; induces cell-cycle arrest at the G2-M phase.


Chemical Structure

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NU6140
CAS# 444723-13-1

Theoretical Analysis

MedKoo Cat#: 406352
Name: NU6140
CAS#: 444723-13-1
Chemical Formula: C23H30N6O2
Exact Mass: 422.24302
Molecular Weight: 422.52
Elemental Analysis: C, 65.38; H, 7.16; N, 19.89; O, 7.57

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 750 2 Weeks
50mg USD 1350 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-03. Prices are subject to change without notice.

NU6140, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: NU6140; NU-6140; NU 6140.

IUPAC/Chemical Name: 4-((6-(cyclohexylmethoxy)-1H-purin-2-yl)amino)-N,N-diethylbenzamide

InChi Key: XHEQSRJCJTWWAH-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)

SMILES Code: O=C(N(CC)CC)C1=CC=C(NC2=NC3=NC=NC3=C(OCC4CCCCC4)N2)C=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
soluble in DMSO, not soluble in water

Shelf Life:
>2 years if stored properly.

Drug Formulation:
This drug may be formulated in DMSO.

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 422.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang LZ, Curtin N, Golding  BT, Griffin RJ, Hardcastle IR, Henderson A, Zaffaroni N, Newell DR. Potentiation  of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. PubMed PMID: 16170024.



Additional Information