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MedKoo CAT#: 406361

CAS#: 188106-83-4

Description: NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h.

Price and Availability

Size Price Shipping out time Quantity
250mg USD 280 2 Weeks
1g USD 540 2 Weeks
5g USD 1390 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-16. Prices are subject to change without notice.

NU1085, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406361
Name: NU1085
CAS#: 188106-83-4
Chemical Formula: C14H11N3O2
Exact Mass: 253.08513
Molecular Weight: 253.26
Elemental Analysis: C, 66.40; H, 4.38; N, 16.59; O, 12.63

Synonym: NU1085; NU-1085; NU 1085.

IUPAC/Chemical Name: 2-(4-hydroxyphenyl)-1H-benzo[d]imidazole-7-carboxamide


InChi Code: InChI=1S/C14H11N3O2/c15-13(19)10-2-1-3-11-12(10)17-14(16-11)8-4-6-9(18)7-5-8/h1-7,18H,(H2,15,19)(H,16,17)

SMILES Code: O=C(C1=C2NC(C3=CC=C(O)C=C3)=NC2=CC=C1)N

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



1: Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6(7):2860-7. PubMed PMID: 10914735.