WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406513
Description: MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of the mitotic marker MPM-2. Furthermore, the compound induced apoptotic cell death through mitochondria/caspase 9-dependent pathway. Notably, several KB-derived multidrug-resistant cancer cell lines were also sensitive to MPT0B214 treatment. ( PLoS One. 2013;8(3):e58953).
MedKoo Cat#: 406513
Chemical Formula: C20H20N2O5
Exact Mass: 368.13722
Molecular Weight: 368.38
Elemental Analysis: C, 65.21; H, 5.47; N, 7.60; O, 21.72
MPT0B214 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: MPT0B214; MPT 0B214; MPT-0B214
IUPAC/Chemical Name: (5-amino-6-methoxyquinolin-2-yl)(3,4,5-trimethoxyphenyl)methanone
InChi Key: HBQYPNDXFXSVNP-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N2O5/c1-24-15-8-7-13-12(18(15)21)5-6-14(22-13)19(23)11-9-16(25-2)20(27-4)17(10-11)26-3/h5-10H,21H2,1-4H3
SMILES Code: O=C(C1=NC2=CC=C(OC)C(N)=C2C=C1)C3=CC(OC)=C(OC)C(OC)=C3
The following data is based on the product molecular weight 368.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chiang NJ, Lin CI, Liou JP, Kuo CC, Chang CY, Chen LT, Chang JY. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway. PLoS One. 2013;8(3):e58953. doi: 10.1371/journal.pone.0058953. Epub 2013 Mar 12. PubMed PMID: 23554962; PubMed Central PMCID: PMC3595215.