WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401555
Description: MNBA, also known as 4-methyl-3-nitro-benzoic acid, is a potential cell migration inhibitor, with potential anticancer activity. T reatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug . (source: Cancer Lett. 2011 Jun 1;305(1):69-75. doi: 10.1016/j.canlet.2011.02.028. Epub 2011 Mar 22.).
MedKoo Cat#: 401555
Name: MNBA (4-methyl-3-nitro-benzoic acid)
Chemical Formula: C8H7NO4
Exact Mass: 181.03751
Molecular Weight: 181.14548
Elemental Analysis: C, 53.04; H, 3.89; N, 7.73; O, 35.33
MNBA (4-methyl-3-nitro-benzoic acid) is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: MNBA; 4methyl3nitrobenzoic acid
IUPAC/Chemical Name: 4-methyl-3-nitro-benzoic acid
InChi Key: BBEWSMNRCUXQRF-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H7NO4/c1-5-2-3-6(8(10)11)4-7(5)9(12)13/h2-4H,1H3,(H,10,11)
SMILES Code: O=C(O)C1=CC=C(C)C([N+]([O-])=O)=C1
The following data is based on the product molecular weight 181.14548 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chen P, Zhang X, Guo H, Ma N, Li M, Liu Z, Zhang N, Hao X. Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration. Mol Med Report. 2011 Sep-Oct;4(5):947-53. doi: 10.3892/mmr.2011.527. Epub 2011 Jul 1. PubMed PMID: 21725598.
2: Guo H, Li M, Chen P, Blake DJ, Kong X, Hao X, Niu R, Zhang N. 4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice. Cancer Lett. 2011 Jun 1;305(1):69-75. doi: 10.1016/j.canlet.2011.02.028. Epub 2011 Mar 22. Erratum in: Cancer Lett. 2012 Nov 28;324(2):232. PubMed PMID: 21429660.