ML-132

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406364

CAS#: 1230628-71-3

Description: ML132, also known as CID-4462093 or NCGC-00183434, is the most potent caspase 1 inhibitor reported to date. It also possesses a unique selectivity pattern relative to other reported caspase inhibitors.


Chemical Structure

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ML-132
CAS# 1230628-71-3

Theoretical Analysis

MedKoo Cat#: 406364
Name: ML-132
CAS#: 1230628-71-3
Chemical Formula: C22H28ClN5O5
Exact Mass: 477.18
Molecular Weight: 477.941
Elemental Analysis: C, 55.29; H, 5.90; Cl, 7.42; N, 14.65; O, 16.74

Price and Availability

Size Price Availability Quantity
10mg USD -2
25mg USD -2
50mg USD -2
100mg USD -2
200mg USD -2
500mg USD -2
1g USD -1
2g USD -1
5g USD -1
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Synonym: ML132; ML 132; ML-132; CID-4462093; CID4462093;CID 4462093; NCGC00183434; NCGC 00183434; NCGC-00183434.

IUPAC/Chemical Name: (S)-3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoic acid

InChi Key: KENKPOUHXLJLEY-QANKJYHBSA-N

InChi Code: InChI=1S/C22H28ClN5O5/c1-22(2,3)18(27-19(31)12-6-7-15(25)14(23)9-12)21(33)28-8-4-5-16(28)20(32)26-13(11-24)10-17(29)30/h6-7,9,13,16,18H,4-5,8,10,25H2,1-3H3,(H,26,32)(H,27,31)(H,29,30)/t13-,16-,18+/m0/s1

SMILES Code: O=C(O)C[C@H](NC([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)=O)C#N

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 477.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Boxer MB, Shen M, Auld DS, Wells JA, Thomas CJ. A small molecule inhibitor of  Caspase 1. 2010 Feb 25 [updated 2011 Mar 3]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK56241/PubMed PMID: 21735610. or

http://www.ncbi.nlm.nih.gov/pubmed/21735610