Mizoribine
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406375

CAS#: 50924-49-7

Description: Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum. Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases.


Chemical Structure

img
Mizoribine
CAS# 50924-49-7

Theoretical Analysis

MedKoo Cat#: 406375
Name: Mizoribine
CAS#: 50924-49-7
Chemical Formula: C9H13N3O6
Exact Mass: 259.08044
Molecular Weight: 259.22
Elemental Analysis: C, 41.70; H, 5.05; N, 16.21; O, 37.03

Size Price Shipping out time Quantity
200mg USD 90 Same day
500mg USD 150 Same day
1g USD 250 Same day
2g USD 450 Same day
5g USD 950 Same day
10g USD 1650 Same day
100g USD 7950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-02. Prices are subject to change without notice.

Mizoribine, purity > 98%, is in stock. The same day shipping out after order is received.

Synonym: Mizoribine; Bredinin; HE 69; He69; He-69; NSC289637; NSC-289637; NSC 289637.

IUPAC/Chemical Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxy-1H-imidazole-4-carboxamide

InChi Key: HZQDCMWJEBCWBR-UUOKFMHZSA-N

InChi Code: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

SMILES Code: O=C(C1=C(O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=N1)N

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 259.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhang X, Fu S, Han S, Zheng X, Wang L. The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review. Transpl Immunol. 2013 Mar;28(2-3):106-11. doi: 10.1016/j.trim.2012.12.003. Epub 2013 Jan 9. Review. PubMed PMID: 23313278.

2: Sawada T. [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine]. Nihon Naika Gakkai Zasshi. 2011 Oct 10;100(10):2929-35. Review. Japanese. PubMed PMID: 22175133.

3: Kawasaki Y. Mizoribine: a new approach in the treatment of renal disease. Clin Dev Immunol. 2009;2009:681482. doi: 10.1155/2009/681482. Epub 2009 Dec 13. Review. PubMed PMID: 20052390; PubMed Central PMCID: PMC2801010.

4: Kondo H, Iizuka N. [Mizoribine]. Nihon Rinsho. 2005 May;63 Suppl 5:708-12. Review. Japanese. PubMed PMID: 15954433.

5: Tanaka H, Abe T, Nishimura S, Sakai H, Kimura H, Oki M, Nojima M, Taga M, Matsumoto S, Takahashi H, Imai K. [A case of rheumatoid arthritis/Sjogren's syndrome with acute renal failure due to hyperuricemia associated with mizoribine therapy]. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Jun;27(3):171-6. Review. Japanese. PubMed PMID: 15291254.

6: Tsuzuki K. Role of mizoribine in renal transplantation. Pediatr Int. 2002 Apr;44(2):224-31. Review. PubMed PMID: 11896891.

7: Honda M. Nephrotic syndrome and mizoribine in children. Pediatr Int. 2002 Apr;44(2):210-6. Review. PubMed PMID: 11896889.

8: Takei S. Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Pediatr Int. 2002 Apr;44(2):205-9. Review. PubMed PMID: 11896888.

9: Yokota S. Mizoribine: mode of action and effects in clinical use. Pediatr Int. 2002 Apr;44(2):196-8. Review. PubMed PMID: 11896886.

10: Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575-97. Review. PubMed PMID: 10390602.



Additional Information

 MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division. Thus, MZB has less toxicity than azathioprine, another immunosuppressant used for some of the same diseases. (http://en.wikipedia.org/wiki/Mizoribine) (Last updated: 8/06/2015)