LQB-118

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406115

CAS#: 1219104-20-7

Description: LQB-118 is an orally active pterocarpanquinone molecule with potential anticancer activity. LQB-118 may have potential therapeutic value for leukemia, being able to overcome multiple resistance mechanisms.


Chemical Structure

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LQB-118
CAS# 1219104-20-7

Theoretical Analysis

MedKoo Cat#: 406115
Name: LQB-118
CAS#: 1219104-20-7
Chemical Formula: C19H12O4
Exact Mass: 304.07356
Molecular Weight: 304.3
Elemental Analysis: C, 74.99; H, 3.97; O, 21.03

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Synonym: LQB118; LQB 118; LQB-118

IUPAC/Chemical Name: (7aS,12aS)-7,7a-dihydro-5H-benzo[g]benzofuro[3,2-c]chromene-5,13(12aH)-dione

InChi Key: BUEHOQICFGQBNY-ACJLOTCBSA-N

InChi Code: InChI=1S/C19H12O4/c20-16-11-6-1-2-7-12(11)17(21)19-15(16)18-13(9-22-19)10-5-3-4-8-14(10)23-18/h1-8,13,18H,9H2/t13-,18+/m1/s1

SMILES Code: O=C1C2=CC=CC=C2C(C3=C1OC[C@@]4([H])[C@]3([H])OC5=CC=CC=C54)=O

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 304.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Jan 3. [Epub ahead of print] PubMed PMID: 23288404.

2: de Sá Bacelar T, da Silva AJ, Costa PR, Rumjanek VM. The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway. Anticancer Drugs. 2013 Jan;24(1):73-83. doi: 10.1097/CAD.0b013e3283592da8. PubMed PMID: 22960938.

3: de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, Vasconcelos FD, Bello RD, da Silva AJ, Costa PR, Maia RC. The Therapeutical Potential of A Novel Pterocarpanquinone LQB-118 to Target Inhibitor Of Apoptosis Proteins In Acute Myeloid Leukemia Cells. Anticancer Agents Med Chem. 2012 Jun 18. [Epub ahead of print] PubMed PMID: 22721384.

4: da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC. Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis. J Antimicrob Chemother. 2011 Jul;66(7):1555-9. doi: 10.1093/jac/dkr158. Epub 2011 Apr 29. PubMed PMID: 21531758.

5: Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells. Invest New Drugs. 2011 Dec;29(6):1143-55. doi: 10.1007/s10637-010-9453-z. Epub 2010 May 25. PubMed PMID: 20499132.

LQB-118

10.0mg / Not available


Additional Information