WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406301
CAS#: 160141-09-3
Description: L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity.
MedKoo Cat#: 406301
Name: L-744832
CAS#: 160141-09-3
Chemical Formula: C26H45N3O6S2
Exact Mass: 559.27498
Molecular Weight: 559.782
Elemental Analysis: C, 55.79; H, 8.10; N, 7.51; O, 17.15; S, 11.46
L-744832, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: L744832; L 744832; L-744832
IUPAC/Chemical Name: (S)-isopropyl 2-((S)-2-(((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate
InChi Key: PGOKBMWPBDRDGN-IBXSQZDTSA-N
InChi Code: InChI=1S/C26H45N3O6S2/c1-6-19(4)23(28-15-21(27)17-36)16-34-24(14-20-10-8-7-9-11-20)25(30)29-22(12-13-37(5,32)33)26(31)35-18(2)3/h7-11,18-19,21-24,28,36H,6,12-17,27H2,1-5H3,(H,29,30)/t19-,21+,22-,23+,24-/m0/s1
SMILES Code: O=C(OC(C)C)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O
The following data is based on the product molecular weight 559.782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams
RT, Wang Y, Ablao KP. Statin treatment increases lifespan and improves cardiac
health in Drosophila by decreasing specific protein prenylation. PLoS One.
2012;7(6):e39581. doi: 10.1371/journal.pone.0039581. Epub 2012 Jun 21. PubMed
PMID: 22737247; PubMed Central PMCID: PMC3380867.
2: Murphy LA, Moore T, Nesnow S. Propiconazole-enhanced hepatic cell
proliferation is associated with dysregulation of the cholesterol biosynthesis
pathway leading to activation of Erk1/2 through Ras farnesylation. Toxicol Appl
Pharmacol. 2012 Apr 15;260(2):146-54. doi: 10.1016/j.taap.2012.02.003. Epub 2012
Feb 14. PubMed PMID: 22361350.