KR30031

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406356

CAS#: 205535-74-6

Description: KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031.


Chemical Structure

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KR30031
CAS# 205535-74-6

Theoretical Analysis

MedKoo Cat#: 406356
Name: KR30031
CAS#: 205535-74-6
Chemical Formula: C26H34N2O4
Exact Mass: 438.25186
Molecular Weight: 438.56
Elemental Analysis: C, 71.21; H, 7.81; N, 6.39; O, 14.59

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

KR30031 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: KR30031; KR-30031; KR 30031.

IUPAC/Chemical Name: 1-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-4,5-dimethoxy-2,3-dihydro-1H-indene-1-carbonitrile

InChi Key: VLSLFQMGJUJBQJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H34N2O4/c1-28(16-12-19-7-9-22(29-2)24(17-19)31-4)15-6-13-26(18-27)14-11-20-21(26)8-10-23(30-3)25(20)32-5/h7-10,17H,6,11-16H2,1-5H3

SMILES Code: N#CC1(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=C1C=CC(OC)=C3OC

Appearance:
white to off-white solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition:
0 – 4 C for short term (weeks to 1 month) or -20 C for long terms (months to years).

Solubility:
soluble in DMSO, not soluble in water

Shelf Life:
>2 years if stored properly.

Drug Formulation:
this drug may be formulated in DMSO.

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 438.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Werle M. Polymeric and low molecular mass efflux pump inhibitors for oral drug delivery. J Pharm Sci. 2008 Jan;97(1):60-70. Review. PubMed PMID: 17721883.

2: Kim DW, Kwon JS, Kim YG, Kim MS, Lee GS, Youn TJ, Cho MC. Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model. Circulation. 2004 Mar 30;109(12):1558-63. Epub 2004 Mar 8. PubMed PMID: 15006998.

3: Woo JS, Lee CH, Shim CK, Hwang SJ. Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031. Pharm Res. 2003 Jan;20(1):24-30. PubMed PMID: 12608532.

4: Lee BH, Lee CO, Kwon MJ, Yi KY, Yoo SE, Choi SU. Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity. Anticancer Drugs. 2003 Feb;14(2):175-81. PubMed PMID: 12569305.

KR30031

10mg / Not available


Additional Information