WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406404
CAS#: 930089-25-1
Description: KI-328 is a novel KIT inhibitor. KI-328 shows selective potency against KIT kinase for the in vitro kinase assay, and inhibits the growth of wild-type (Wt)- and mutant-KIT-expressing cells, while it has little potency against D816V-KIT.
MedKoo Cat#: 406404
Name: KI-328
CAS#: 930089-25-1
Chemical Formula: C25H25N7O3
Exact Mass: 471.20189
Molecular Weight: 471.51
Elemental Analysis: C, 63.68; H, 5.34; N, 20.79; O, 10.18
Synonym: KI328; KI 328; KI-328.
IUPAC/Chemical Name: methyl (4-(2-((5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-(phenylamino)pyrimidin-2-yl)amino)ethyl)phenyl)carbamate
InChi Key: DRWABHOVZJWFLU-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H25N7O3/c1-34-25(33)29-19-11-7-16(8-12-19)13-14-26-24-27-15-20(23-32-31-22(35-23)17-9-10-17)21(30-24)28-18-5-3-2-4-6-18/h2-8,11-12,15,17H,9-10,13-14H2,1H3,(H,29,33)(H2,26,27,28,30)
SMILES Code: O=C(OC)NC1=CC=C(CCNC2=NC=C(C3=NN=C(C4CC4)O3)C(NC5=CC=CC=C5)=N2)C=C1
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 471.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T. Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia. Int J Hematol. 2010 Nov;92(4):624-33. doi: 10.1007/s12185-010-0692-8. Epub 2010 Oct 5. PubMed PMID: 20890793.
