WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406157
Description: ISC-4 is an Akt inhibitor, which activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.
MedKoo Cat#: 406157
Chemical Formula: C11H13NSe
Exact Mass: 239.02132
Molecular Weight: 238.19
Elemental Analysis: C, 55.47; H, 5.50; N, 5.88; Se, 33.15
Synonym: ISC4, ISC-4, ISC 4
IUPAC/Chemical Name: (4-isoselenocyanatobutyl)benzene
InChi Key: NMPQIJIERCLTOG-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H13NSe/c13-10-12-9-5-4-8-11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-9H2
SMILES Code: [Se]=C=NCCCCC1=CC=CC=C1
Appearance: Solid powder
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 238.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sharma AK, Kline CL, Berg A, Amin S, Irby RB. The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. Clin Cancer Res. 2011 Jul 1;17(13):4474-83. doi: 10.1158/1078-0432.CCR-10-2370. Epub 2011 May 9. PubMed PMID: 21555373; PubMed Central PMCID: PMC3131476.