WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401512
CAS#: 931398-72-0
Description: IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.
MedKoo Cat#: 401512
Name: IOX 2
CAS#: 931398-72-0
Chemical Formula: C19H16N2O5
Exact Mass: 352.10592
Molecular Weight: 352.34
Elemental Analysis: C, 64.77; H, 4.58; N, 7.95; O, 22.70
Synonym: IOX2; IOX-2; IOX 2
IUPAC/Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
SMILES Code: O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
Appearance: Solid powder
Purity: >98%
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 352.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C.
Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts
by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol.
2015 Jun 17. [Epub ahead of print] PubMed PMID: 26082309.
2: Egert AM, Klotz JL, McLeod KR, Harmon DL. Development of a methodology to
measure the effect of ergot alkaloids on forestomach motility using real-time
wireless telemetry. Front Chem. 2014 Oct 13;2:90. doi: 10.3389/fchem.2014.00090.
eCollection 2014. PubMed PMID: 25353021; PubMed Central PMCID: PMC4195290.
3: Sen A, Ren S, Lerchenmüller C, Sun J, Weiss N, Most P, Peppel K. MicroRNA-138
regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS
One. 2013 Nov 11;8(11):e78684. doi: 10.1371/journal.pone.0078684. eCollection
2013. Erratum in: PLoS One. 2013;8(12).
doi:10.1371/annotation/53080a85-89cc-4a84-8fd9-0eb0c19cc05d. PLoS One. 2014;9(1).
doi:10.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b6. PubMed PMID:
24244340; PubMed Central PMCID: PMC3823839.
