WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401512
CAS#: 931398-72-0
Description: IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.
MedKoo Cat#: 401512
Name: IOX 2
CAS#: 931398-72-0
Chemical Formula: C19H16N2O5
Exact Mass: 352.10592
Molecular Weight: 352.34
Elemental Analysis: C, 64.77; H, 4.58; N, 7.95; O, 22.70
IOX 2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: IOX2; IOX-2; IOX 2
IUPAC/Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
InChi Key: CAOSCCRYLYQBES-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
SMILES Code: O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
The following data is based on the product molecular weight 352.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C.
Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts
by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol.
2015 Jun 17. [Epub ahead of print] PubMed PMID: 26082309.
2: Egert AM, Klotz JL, McLeod KR, Harmon DL. Development of a methodology to
measure the effect of ergot alkaloids on forestomach motility using real-time
wireless telemetry. Front Chem. 2014 Oct 13;2:90. doi: 10.3389/fchem.2014.00090.
eCollection 2014. PubMed PMID: 25353021; PubMed Central PMCID: PMC4195290.
3: Sen A, Ren S, Lerchenmüller C, Sun J, Weiss N, Most P, Peppel K. MicroRNA-138
regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS
One. 2013 Nov 11;8(11):e78684. doi: 10.1371/journal.pone.0078684. eCollection
2013. Erratum in: PLoS One. 2013;8(12).
doi:10.1371/annotation/53080a85-89cc-4a84-8fd9-0eb0c19cc05d. PLoS One. 2014;9(1).
doi:10.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b6. PubMed PMID:
24244340; PubMed Central PMCID: PMC3823839.