Indimitecan

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 402501

CAS#: 915360-05-3

Description: Indimitecan, also known as LMP776, is a novel topoisomerase I inhibitor.

Chemical Structure

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Indimitecan
CAS# 915360-05-3
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 402501
Name: Indimitecan
CAS#: 915360-05-3
Chemical Formula: C25H23N3O6
Exact Mass: 461.15869
Molecular Weight: 461.47
Elemental Analysis: C, 65.07; H, 5.02; N, 9.11; O, 20.80

Size Price Shipping out time Quantity
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Pricing updated 2021-03-06. Prices are subject to change without notice.

Indimitecan is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: Indimitecan; LMP776; LM P776; LM-P776

IUPAC/Chemical Name: 6-(3-(1H-imidazol-1-yl)propyl)-2,3-dimethoxy-6,6a-dihydro-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(12aH)-dione

InChi Key: ZXJNJZLQVSYONH-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H23N3O6/c1-31-18-8-14-17(11-19(18)32-2)25(30)28(6-3-5-27-7-4-26-12-27)23-15-9-20-21(34-13-33-20)10-16(15)24(29)22(14)23/h4,7-12,22-23H,3,5-6,13H2,1-2H3

SMILES Code: O=C1N(CCCN2C=CN=C2)C3C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6

Appearance:
Solid powder

Purity:
>98%

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 461.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. doi: 10.1021/jm300519w. Epub 2012 Dec 7. PubMed PMID: 23215354.

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Indimitecan

10mg / Not available


Additional Information