WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 402501
CAS#: 915360-05-3
Description: Indimitecan, also known as LMP776, is a novel topoisomerase I inhibitor.
MedKoo Cat#: 402501
Name: Indimitecan
CAS#: 915360-05-3
Chemical Formula: C25H23N3O6
Exact Mass: 461.15869
Molecular Weight: 461.47
Elemental Analysis: C, 65.07; H, 5.02; N, 9.11; O, 20.80
Synonym: Indimitecan; LMP776; LM P776; LM-P776
IUPAC/Chemical Name: 6-(3-(1H-imidazol-1-yl)propyl)-2,3-dimethoxy-6,6a-dihydro-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(12aH)-dione
InChi Key: ZXJNJZLQVSYONH-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H23N3O6/c1-31-18-8-14-17(11-19(18)32-2)25(30)28(6-3-5-27-7-4-26-12-27)23-15-9-20-21(34-13-33-20)10-16(15)24(29)22(14)23/h4,7-12,22-23H,3,5-6,13H2,1-2H3
SMILES Code: O=C1N(CCCN2C=CN=C2)C3C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6
Appearance: Solid powder
Purity: >98%
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 461.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Cinelli MA, Reddy PV, Lv PC, Liang JH, Chen L, Agama K, Pommier Y, van Breemen RB, Cushman M. Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons. J Med Chem. 2012 Dec 27;55(24):10844-62. doi: 10.1021/jm300519w. Epub 2012 Dec 7. PubMed PMID: 23215354.
