WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406509
Description: HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5):1169-78. )
MedKoo Cat#: 406509
Chemical Formula: C23H22N2O4
Exact Mass: 390.15796
Molecular Weight: 390.43
Elemental Analysis: C, 70.75; H, 5.68; N, 7.17; O, 16.39
Synonym: HACY6; HAC-Y6; HAC Y6.
IUPAC/Chemical Name: 1-(9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indol-6-yl)ethanone
InChi Key: NYMMDHGEECPYAW-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H22N2O4/c1-14(26)16-7-8-19-18(12-16)17-6-5-9-24-23(17)25(19)13-15-10-20(27-2)22(29-4)21(11-15)28-3/h5-12H,13H2,1-4H3
SMILES Code: CC(C1=CC2=C(N(CC3=CC(OC)=C(OC)C(OC)=C3)C4=NC=CC=C42)C=C1)=O
Appearance: white solid powder
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 390.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lin YC, Tsai JY, Yang JS, Lee YH, Hamel E, Lee KH, Kuo SC, Huang LJ. The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. Int J Oncol. 2013 Nov;43(5):1596-606. doi: 10.3892/ijo.2013.2069. Epub 2013 Aug 21. PubMed PMID: 23970288.
2: Tsai JY, Hung CM, Bai ST, Huang CH, Chen WC, Chung JG, Kuo SC, Way TD, Huang LJ. Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells. Oncol Rep. 2010 Nov;24(5):1169-78. PubMed PMID: 20878107