GTP-14564
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406205

CAS#: 34823-86-4

Description: GTP-14564 is a specific kinase inhibitor for ITD-FLT3. GTP-14564 inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3 at 1 microM, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).


Chemical Structure

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GTP-14564
CAS# 34823-86-4

Theoretical Analysis

MedKoo Cat#: 406205
Name: GTP-14564
CAS#: 34823-86-4
Chemical Formula: C15H10N2O
Exact Mass: 234.07931
Molecular Weight: 234.25
Elemental Analysis: C, 76.91; H, 4.30; N, 11.96; O, 6.83

Price and Availability

Size Price Availability Quantity
5.0mg USD 270.0 2 Weeks
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Synonym: GTP14564; GTP 14564; GTP-14564

IUPAC/Chemical Name: 3-phenyl-1H-benzofuro[3,2-c]pyrazole

InChi Key: DZQLVVLATXPWBK-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)

SMILES Code: C12=C(OC3=CC=CC=C32)C(C4=CC=CC=C4)=NN1

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 234.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yao Q, Nishiuchi R, Kitamura T, Kersey JH. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia. 2005 Sep;19(9):1605-12. PubMed PMID: 16034464.

2: Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18. PubMed PMID: 12815052.



Additional Information