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MedKoo CAT#: 406136

CAS#: 133053-19-7

Description: GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 4250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-24. Prices are subject to change without notice.

GO6983, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406136
Name: Go6983
CAS#: 133053-19-7
Chemical Formula: C26H26N4O3
Exact Mass: 442.20049
Molecular Weight: 442.51
Elemental Analysis: C, 70.57; H, 5.92; N, 12.66; O, 10.85

Synonym: Go6983 Go-6983; Go 6983; GO6983; GO 6983; GO-6983

IUPAC/Chemical Name: 3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione


InChi Code: InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)


Technical Data

Solid powder


Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



1: Dai B, Zhang J, Liu M, Lu J, Zhang Y, Xu Y, Miao J, Yin Y. The role of Ca(2+) mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Vet Microbiol. 2016 Aug 30;192:26-33. doi: 10.1016/j.vetmic.2016.06.008. PubMed PMID: 27527761.

2: Olianas MC, Dedoni S, Onali P. Protection from interferon-β-induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation. Br J Pharmacol. 2016 Oct;173(19):2910-28. doi: 10.1111/bph.13570. PubMed PMID: 27474091.

3: Hu SY, Tong GJ, Meng Y, Hao S, Li W, Xu FL, He YH, Chen JT, Yang DH. [Parathyroid hormone inhibits the apoptosis of osteoblast MC-3T3E1 cells through a non-PLC-dependent protein kinase C pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jun;36(6):785-9. Chinese. PubMed PMID: 27320879.

4: Meng Z, Bischof J, Ianes C, Henne-Bruns D, Xu P, Knippschild U. CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation. Amino Acids. 2016 May;48(5):1185-97. doi: 10.1007/s00726-015-2154-3. PubMed PMID: 26803658.

5: Jian Y, Chen C, Li B, Tian X. Delocalized Claudin-1 promotes metastasis of human osteosarcoma cells. Biochem Biophys Res Commun. 2015 Oct 23;466(3):356-61. doi: 10.1016/j.bbrc.2015.09.028. PubMed PMID: 26361141.

6: Thengchaisri N, Hein TW, Ren Y, Kuo L. Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase. J Mol Cell Cardiol. 2015 Sep;86:75-84. doi: 10.1016/j.yjmcc.2015.07.014. PubMed PMID: 26211713; PubMed Central PMCID: PMC4558216.

7: Wei X, Zhang B, Cheng L, Chi M, Deng L, Pan H, Yao X, Wang G. Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. Brain Res. 2015 Oct 5;1622:292-9. doi: 10.1016/j.brainres.2015.07.001. PubMed PMID: 26168888.

8: Alcantara C, Maza PK, Barros BC, Suzuki E. Role of protein kinase C in cytokine secretion by lung epithelial cells during infection with Paracoccidioides brasiliensis. Pathog Dis. 2015 Oct;73(7). pii: ftv045. doi: 10.1093/femspd/ftv045. PubMed PMID: 26152710; PubMed Central PMCID: PMC4626587.

9: Xu H, Czerwinski P, Xia N, Förstermann U, Li H. Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. Pharmacology. 2015;96(1-2):1-10. doi: 10.1159/000430823. PubMed PMID: 26021525.

10: Hao S, Meng Y, Li W, Hu SY, Yang DH. [Activation of phospholipase C-independent protein kinase C signaling pathway of parathyroid hormone enhances CITED1 expression in mouse osteoblasts]. Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):486-91. Chinese. PubMed PMID: 25907930.

11: Hou J, Wang Z, Xu H, Yang L, Yu X, Yang Z, Deng Y, Meng J, Feng Y, Guo X, Yang G. Stanniocalicin 2 suppresses breast cancer cell migration and invasion via the PKC/claudin-1-mediated signaling. PLoS One. 2015 Apr 1;10(4):e0122179. doi: 10.1371/journal.pone.0122179. PubMed PMID: 25830567; PubMed Central PMCID: PMC4382185.

12: Ikari A, Fujii N, Hahakabe S, Hayashi H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J. Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. J Cell Physiol. 2015 Nov;230(11):2776-87. doi: 10.1002/jcp.25004. PubMed PMID: 25825272.

13: Hori T, Barnor J, Huu TN, Morinaga O, Hamano A, Ndzinu J, Frimpong A, Minta-Asare K, Amoa-Bosompem M, Brandful J, Odoom J, Bonney J, Tuffour I, Owusu BA, Ofosuhene M, Atchoglo P, Sakyiamah M, Adegle R, Appiah-Opong R, Ampofo W, Koram K, Nyarko A, Okine L, Edoh D, Appiah A, Uto T, Yoshinaka Y, Uota S, Shoyama Y, Yamaoka S. Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus. Biochem Biophys Res Commun. 2015 Apr 3;459(2):288-93. doi: 10.1016/j.bbrc.2015.02.102. Erratum in: Biochem Biophys Res Commun. 2015 Jun 12;461(4):702. PubMed PMID: 25727021.

14: Hsu H, Baldwin CL, Telfer JC. The endocytosis and signaling of the γδ T cell coreceptor WC1 are regulated by a dileucine motif. J Immunol. 2015 Mar 1;194(5):2399-406. doi: 10.4049/jimmunol.1402020. PubMed PMID: 25632004.

15: Bian JM, Wu N, Su RB, Li J. Phosphatidylethanolamine-binding protein is not involved in µ-opioid receptor-mediated regulation of extracellular signal-regulated kinase. Mol Med Rep. 2015 May;11(5):3368-74. doi: 10.3892/mmr.2015.3161. PubMed PMID: 25573435; PubMed Central PMCID: PMC4368089.

16: Kuan CS, Yee YH, See Too WC, Few LL. Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckβ promoter via the protein kinase C signaling pathway. PLoS One. 2014 Dec 9;9(12):e113485. doi: 10.1371/journal.pone.0113485. PubMed PMID: 25490397; PubMed Central PMCID: PMC4260826.

17: Kawata J, Aoki M, Ishimaru Y, Ono T, Sagara K, Narahara S, Matsmoto T, Hirose E, Yamaguchi Y. Mechanism of tissue factor production by monocytes stimulated with neutrophil elastase. Blood Cells Mol Dis. 2015 Feb;54(2):206-9. doi: 10.1016/j.bcmd.2014.10.005. PubMed PMID: 25465717.

18: Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Mol Pharmacol. 2014 Oct;86(4):406-16. doi: 10.1124/mol.114.092403. PubMed PMID: 25086086.

19: Lin Z, Feng R, Li J, Meng Y, Yuan L, Fu Z, Guo J, Bringhurst FR, Yang D. Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid hormone requires serine phosphorylation at position 79 in its 63-84 domain. Cell Signal. 2014 Nov;26(11):2436-45. doi: 10.1016/j.cellsig.2014.06.015. PubMed PMID: 25049079.

20: Yan H, Ma YL, Gui YZ, Wang SM, Wang XB, Gao F, Wang YP. MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression. Acta Pharmacol Sin. 2014 Aug;35(8):994-1004. doi: 10.1038/aps.2014.52. PubMed PMID: 25042549; PubMed Central PMCID: PMC4125719.