WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406427
CAS#: 1033769-28-6
Description: GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
MedKoo Cat#: 406427
Name: GNF-5837
CAS#: 1033769-28-6
Chemical Formula: C28H21F4N5O2
Exact Mass: 535.16314
Molecular Weight: 535.49225
Elemental Analysis: C, 62.80; H, 3.95; F, 14.19; N, 13.08; O, 5.98
Synonym: GNF5837; GNF-5837; GNF 5837.
IUPAC/Chemical Name: (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
InChi Key: YYDUWLSETXNJJT-MTJSOVHGSA-N
InChi Code: InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2
Appearance: Orange to red solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 535.49225 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Pam Albaugh , Yi Fan , Yuan Mi , Fangxian Sun , Francisco Adrian , Nanxin Li , Yong Jia , Yelena Sarkisova , Andreas Kreusch , Tami Hood , Min Lu , Guoxun Liu , Shenlin Huang , Zuosheng Liu , Jon Loren , Tove Tuntland , Donald S. Karanewsky , H. Martin Seidel , and Valentina Molteni. Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med. Chem. Lett., 2012, 3 (2), pp 140–145.
