GNF-5837
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MedKoo CAT#: 406427

CAS#: 1033769-28-6

Description: GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of GNF-5837 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.


Chemical Structure

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GNF-5837
CAS# 1033769-28-6

Theoretical Analysis

MedKoo Cat#: 406427
Name: GNF-5837
CAS#: 1033769-28-6
Chemical Formula: C28H21F4N5O2
Exact Mass: 535.16314
Molecular Weight: 535.49225
Elemental Analysis: C, 62.80; H, 3.95; F, 14.19; N, 13.08; O, 5.98

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same day
25.0mg USD 150.0 Same day
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1750.0 Same day
1.0g USD 2950.0 Same day
2.0g USD 4650.0 Same day
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Synonym: GNF5837; GNF-5837; GNF 5837.

IUPAC/Chemical Name: (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

InChi Key: YYDUWLSETXNJJT-MTJSOVHGSA-N

InChi Code: InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-

SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2

Appearance: Orange to red solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 535.49225 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 Pam Albaugh , Yi Fan , Yuan Mi , Fangxian Sun , Francisco Adrian , Nanxin Li , Yong Jia , Yelena Sarkisova , Andreas Kreusch , Tami Hood , Min Lu , Guoxun Liu , Shenlin Huang , Zuosheng Liu , Jon Loren , Tove Tuntland , Donald S. Karanewsky , H. Martin Seidel , and Valentina Molteni. Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med. Chem. Lett., 2012, 3 (2), pp 140–145.



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