Gemcitabine monophosphate disodium salt
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MedKoo CAT#: 406576

CAS#: 1638288-31-9 (disodium)

Description: Gemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine. Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines. (Anticancer Res. 2000 Sep-Oct;20(5A):2915-22).


Chemical Structure

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Gemcitabine monophosphate disodium salt
CAS# 1638288-31-9 (disodium)

Theoretical Analysis

MedKoo Cat#: 406576
Name: Gemcitabine monophosphate disodium salt
CAS#: 1638288-31-9 (disodium)
Chemical Formula: C9H12F2N3Na2O8P
Exact Mass:
Molecular Weight: 405.15811
Elemental Analysis: C, 26.68; H, 2.99; F, 9.38; N, 10.37; Na, 11.35; O, 31.59; P, 7.64

Size Price Shipping out time Quantity
10mg USD 250 Same day
25mg USD 450 Same day
50mg USD 750 Same day
100mg USD 1250 Same day
200mg USD 1950 Same day
500mg USD 2950 Same day
1g USD 4250 Same day
2g USD 7650 Same day
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Pricing updated 2021-03-02. Prices are subject to change without notice.

Gemcitabine monophosphate disodium hydrate, purity > 90%, is in stock.

Related CAS #: 116371-67-6 (free acid)   1638288-31-9 (disodium)    

Synonym: Gemcitabine monophosphate disodium salt monohydrate; Gemcitabine monophosphate disodium; GemMP.

IUPAC/Chemical Name: sodium ((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl phosphate hydrate

InChi Key: YOWQXAMQHWESCE-RBECAVKOSA-L

InChi Code: InChI=1S/C9H12F2N3O7P.2Na.H2O/c10-9(11)6(15)4(3-20-22(17,18)19)21-7(9)14-2-1-5(12)13-8(14)16;;;/h1-2,4,6-7,15H,3H2,(H2,12,13,16)(H2,17,18,19);;;1H2/q;2*+1;/p-2/t4-,6-,7-;;;/m1.../s1

SMILES Code: O=C1N=C(N)C=CN1[C@@H]2O[C@H](COP(O[Na])(O[Na])=O)[C@@H](O)C2(F)F.O

Appearance:
White to off-white solid powder

Purity:
>90% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 405.15811 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Miao L, Guo S, Zhang J, Kim WY, Huang L. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. PubMed PMID: 25395922; PubMed Central PMCID: PMC4225819.



Additional Information