WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406499
Description: G3130 is a reversible Hsp90 inhibitor with potential anticancer activity. G3130 demonstrated cellular activities (in Her-2 degradation and activation of Hsp70 promoter) consistent with the inhibition of cellular Hsp90 functions.
MedKoo Cat#: 406499
Chemical Formula: C14H14N4O2
Exact Mass: 270.11168
Molecular Weight: 270.28656
Elemental Analysis: C, 62.21; H, 5.22; N, 20.73; O, 11.84
This product is not in stock, which may be available by custom synthesis.
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Synonym: G3130; G-3130; G 3130
IUPAC/Chemical Name: 4-(4-(1H-imidazol-4-yl)-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol
InChi Key: ATORUNMAUREKMH-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H14N4O2/c1-2-8-3-9(13(20)4-12(8)19)14-10(5-17-18-14)11-6-15-7-16-11/h3-7,19-20H,2H2,1H3,(H,15,16)(H,17,18)
SMILES Code: OC1=C(CC)C=C(C2=NNC=C2C3=CNC=N3)C(O)=C1
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 270.28656 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shen G, Blagg BS. Radester, a novel inhibitor of the Hsp90 protein folding machinery. Org Lett. 2005 May 26;7(11):2157-60. PubMed PMID: 15901158.