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G007-LK
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558250

CAS#: 1380672-07-0

Description: G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK was first discovered by Dr. Stefan Krauss's team.


Price and Availability

Size Price Shipping out time Quantity
1g USD 3650 2 Weeks
2g USD 5450 2 Weeks
5g USD 9850 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-01-20. Prices are subject to change without notice.

G007-LK, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558250
Name: G007-LK
CAS#: 1380672-07-0
Chemical Formula: C25H16ClN7O3S
Exact Mass: 529.07239
Molecular Weight: 529.95764
Elemental Analysis: C, 56.66; H, 3.04; Cl, 6.69; N, 18.50; O, 9.06; S, 6.05


Synonym: G007LK; G007LK; G007 LK.

IUPAC/Chemical Name: (E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile

InChi Key: HIWVLHPKZNBSBE-OUKQBFOZSA-N

InChi Code: InChI=1S/C25H16ClN7O3S/c1-37(34,35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13,15H,1H3/b13-12+

SMILES Code: N#CC1=CC=C(C2=NN=C(/C=C/C3=NN=C(C4=NC=C(S(=O)(C)=O)C=C4)N3C5=CC=CC=C5Cl)O2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

 License information:

MedKoo licensed the G007-LK patent right from Oslo University, Norway. G007-LK was covered by WO2012076898, pending national/regional patent applications continued from PCT/GB2011/052441 (WO2012/076898).
 
 


References

1: Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A,  Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28. PubMed PMID: 23539443.