WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406466
Description: FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100Â–200 nM).
MedKoo Cat#: 406466
Chemical Formula: C15H23N3O3S2
Exact Mass: 357.11808
Molecular Weight: 357.49142
Elemental Analysis: C, 50.40; H, 6.48; N, 11.75; O, 13.43; S, 17.94
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: FTI249; FTI 249; FTI-249.
IUPAC/Chemical Name: (S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid.
InChi Key: IPZVKZRBOSROBN-YPMHNXCESA-N
InChi Code: InChI=1S/C15H23N3O3S2/c1-23-7-6-13(15(20)21)18-14(19)10-2-4-12(5-3-10)17-8-11(16)9-22/h2-5,11,13,17,22H,6-9,16H2,1H3,(H,18,19)(H,20,21)/t11-,13+/m1/s1
SMILES Code: CSCC[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1)=O
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 357.49142 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Machida S, Tsubamoto M, Kato N, Harada K, Ohkanda J. Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4004-10. doi: 10.1016/j.bmc.2012.09.061. Epub 2012 Oct 11. PubMed PMID: 23107667.