WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406466
CAS#: 161721-65-9
Description: FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100–200 nM).
MedKoo Cat#: 406466
Name: FTI-249
CAS#: 161721-65-9
Chemical Formula: C15H23N3O3S2
Exact Mass: 357.11808
Molecular Weight: 357.49142
Elemental Analysis: C, 50.40; H, 6.48; N, 11.75; O, 13.43; S, 17.94
FTI-249 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: FTI249; FTI 249; FTI-249.
IUPAC/Chemical Name: (S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid.
InChi Key: IPZVKZRBOSROBN-YPMHNXCESA-N
InChi Code: InChI=1S/C15H23N3O3S2/c1-23-7-6-13(15(20)21)18-14(19)10-2-4-12(5-3-10)17-8-11(16)9-22/h2-5,11,13,17,22H,6-9,16H2,1H3,(H,18,19)(H,20,21)/t11-,13+/m1/s1
SMILES Code: CSCC[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1)=O
The following data is based on the product molecular weight 357.49142 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Machida S, Tsubamoto M, Kato N, Harada K, Ohkanda J. Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4004-10. doi: 10.1016/j.bmc.2012.09.061. Epub 2012 Oct 11. PubMed PMID: 23107667.