FTI-249

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406466

CAS#: 161721-65-9

Description: FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100–200 nM).

Chemical Structure

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FTI-249
CAS# 161721-65-9
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406466
Name: FTI-249
CAS#: 161721-65-9
Chemical Formula: C15H23N3O3S2
Exact Mass: 357.11808
Molecular Weight: 357.49142
Elemental Analysis: C, 50.40; H, 6.48; N, 11.75; O, 13.43; S, 17.94

Size Price Shipping out time Quantity
Inquire bulk and customized quantity
Pricing updated 2021-02-27. Prices are subject to change without notice.

FTI-249 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: FTI249; FTI 249; FTI-249.

IUPAC/Chemical Name: (S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid.

InChi Key: IPZVKZRBOSROBN-YPMHNXCESA-N

InChi Code: InChI=1S/C15H23N3O3S2/c1-23-7-6-13(15(20)21)18-14(19)10-2-4-12(5-3-10)17-8-11(16)9-22/h2-5,11,13,17,22H,6-9,16H2,1H3,(H,18,19)(H,20,21)/t11-,13+/m1/s1

SMILES Code: CSCC[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1)=O

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 357.49142 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Machida S, Tsubamoto M, Kato N, Harada K, Ohkanda J. Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4004-10. doi: 10.1016/j.bmc.2012.09.061. Epub 2012 Oct 11. PubMed PMID: 23107667.

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FTI-249



Additional Information