Doxorubicin-SMCC
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406622

CAS#: 400647-59-8

Description: Doxorubicin-SMCC, also known as ADR-SMCC, dox-SMCC, is a derivative of doxorubicin with a SMCC linker (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Maleimide in doxrubicin-SMCC can react with sulfhydryl groups at pH 6.5-7.5 to form a stable thioether bond. Doxorubicin-SMCC can be used to synthesize doxorubicin bioconjugates with proteins, enzymes; antobodies, antigens, and other biopolymers. Doxorubicin-SMCC is often used for drug delivery research.


Chemical Structure

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Doxorubicin-SMCC
CAS# 400647-59-8

Theoretical Analysis

MedKoo Cat#: 406622
Name: Doxorubicin-SMCC
CAS#: 400647-59-8
Chemical Formula: C39H42N2O14
Exact Mass: 762.2636
Molecular Weight: 762.76
Elemental Analysis: C, 61.41; H, 5.55; N, 3.67; O, 29.37

Size Price Shipping out time Quantity
5mg USD 150 Same day
10mg USD 250 Same day
25mg USD 450 Same day
50mg USD 850 Same day
100mg USD 1450 Same day
200mg USD 2450 Same day
500mg USD 3850 Same day
1g USD 5850 Same day
2g USD 9950 Same day
Inquire bulk and customized quantity

Pricing updated 2021-02-25. Prices are subject to change without notice.

Doxorubicin-SMCC, purity > 98%, is in stock. The same day shipping out after order is received.

Synonym: Doxorubicin-SMCC; ADR-SMCC; Dox-SMCC Doxo-SMCC.

IUPAC/Chemical Name: 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)cyclohexanecarboxamide

InChi Key: OTQOQHVWNBKSGU-SAJDXUNTSA-N

InChi Code: InChI=1S/C39H42N2O14/c1-17-33(46)22(40-38(51)19-8-6-18(7-9-19)15-41-26(44)10-11-27(41)45)12-28(54-17)55-24-14-39(52,25(43)16-42)13-21-30(24)37(50)32-31(35(21)48)34(47)20-4-3-5-23(53-2)29(20)36(32)49/h3-5,10-11,17-19,22,24,28,33,42,46,48,50,52H,6-9,12-16H2,1-2H3,(H,40,51)/t17-,18?,19?,22-,24-,28-,33+,39-/m0/s1

SMILES Code: C[C@@H]1O[C@@H](O[C@@H](C2)C3=C(O)C(C4=O)=C(C(C5=C4C(OC)=CC=C5)=O)C(O)=C3C[C@@]2(O)C(CO)=O)C[C@H](NC(C6CCC(CN7C(C=CC7=O)=O)CC6)=O)[C@@H]1O

Appearance:
Red solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 762.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Chen, Q.; Gabathuler, R., Efficient Synthesis of Doxorubicin Melanotransferrin p97 Conjugates Through SMCC Linker. Synth. Commun. 2004, 34, (13), 2407-2414.

2: A Flow Cytometric Clonogenic Assay Reveals the Single-Cell Potency of Doxorubicin Katie F. Maass, Chethana Kulkarni, Mohiuddin A. Quadir, Paula T. Hammond, Alison M. Betts, K. Dane Wittrup J Pharm Sci. Author manuscript; available in PMC 2016 Dec 1.Published in final edited form as: J Pharm Sci. 2015 Dec; 104(12): 4409–4416. Published online 2015 Sep 7. doi: 10.1002/jps.24631 PMCID: PMC4706798



Additional Information