DMAT

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406401

CAS#: NONE

Description: DMAT, also known as 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole, is a potent CK2 inhibitor, which shows anti-neoplastic effect on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. DMAT also induces cell death in antiestrogen resistant human breast cancer cells.


Chemical Structure

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DMAT
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 406401
Name: DMAT
CAS#: NONE
Chemical Formula: C9H7Br4N3
Exact Mass: 472.73735
Molecular Weight: 476.79
Elemental Analysis: C, 22.67; H, 1.48; Br, 67.04; N, 8.81

Size Price Shipping out time Quantity
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Pricing updated 2021-02-26. Prices are subject to change without notice.

DMAT is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: DMAT; 2dimethylamino4567tetrabromobenzimidazole.

IUPAC/Chemical Name: 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine

InChi Key: SLPJGDQJLTYWCI-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15)

SMILES Code: CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 476.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT. Int J Oncol. 2011 Aug;39(2):433-42. doi: 10.3892/ijo.2011.1037. Epub 2011 May 10. PubMed PMID: 21567083.

2: Lawnicka H, Kowalewicz-Kulbat M, Sicinska P, Kazimierczuk Z, Grieb P, Stepien H. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro. Cell Tissue Res. 2010 May;340(2):371-9. doi: 10.1007/s00441-010-0960-1. Epub 2010 Apr 6. PubMed PMID: 20383646.

3: Fritz G, Issinger OG, Olsen BB. Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses. Int J Oncol. 2009 Nov;35(5):1151-7. PubMed PMID: 19787270.

4: Schneider CC, Hessenauer A, Götz C, Montenarh M. DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks. Oncol Rep. 2009 Jun;21(6):1593-7. PubMed PMID: 19424641.

5: Yde CW, Frogne T, Lykkesfeldt AE, Fichtner I, Issinger OG, Stenvang J. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT. Cancer Lett. 2007 Oct 28;256(2):229-37. Epub 2007 Jul 16. PubMed PMID: 17629615.



Additional Information