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MedKoo CAT#: 406247
CAS#: 1202916-90-2 (free base)
Description: CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy.
MedKoo Cat#: 406247
Name: CX-6258
CAS#: 1202916-90-2 (free base)
Chemical Formula: C26H24ClN3O3
Exact Mass: 461.15062
Molecular Weight: 461.94
Elemental Analysis: C, 67.60; H, 5.24; Cl, 7.67; N, 9.10; O, 10.39
Related CAS #: 1202916-90-2 (free base) 1353858-99-7 (HCl hydrate)
Synonym: CX6258; CX-6258; CX 6258.
IUPAC/Chemical Name: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one
InChi Key: KGBPLKOPSFDBOX-CJLVFECKSA-N
InChi Code: InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+
SMILES Code: O=C1NC2=C(C=C(Cl)C=C2)/C1=C\C3=CC=C(C4=CC=CC(C(N5CCN(C)CCC5)=O)=C4)O3
Related CAS#
1202916-90-2 (CX-6258 free base);
1353858-99-7 (CX-6258 HCl salt, hydrate).
1. Mustapha Haddach *, Jerome Michaux , Michael K. Schwaebe , Fabrice Pierre , Sean E. O’Brien , Cosmin Borsan , Joe Tran , Nicholas Raffaele , Suchitra Ravula , Denis Drygin , Adam Siddiqui-Jain , Levan Darjania , Ryan Stansfield , Chris Proffitt , Diwata Macalino , Nicole Streiner , Joshua Bliesath , May Omori , Jeffrey P. Whitten , Kenna Anderes , William G. Rice , and David M. Ryckman. ACS Med. Chem. Lett., 2012, 3 (2), pp 135–139.
