CX-5011

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406402

CAS#: 1009821-06-0 (free acid)

Description: CX-5011 is a very potent and selective CK2 inhibitor, which induces cell death in tumor cells.


Chemical Structure

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CX-5011
CAS# 1009821-06-0 (free acid)

Theoretical Analysis

MedKoo Cat#: 406402
Name: CX-5011
CAS#: 1009821-06-0 (free acid)
Chemical Formula: C20H12N4O2
Exact Mass: 340.09603
Molecular Weight: 340.33
Elemental Analysis: C, 70.58; H, 3.55; N, 16.46; O, 9.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1009821-06-0 (free acid)   1333382-30-1 (sodium)    

Synonym: CX5011; CX-5011; CX 5011.

IUPAC/Chemical Name: 5-((3-ethynylphenyl)amino)pyrimido[4,5-c]quinoline-8-carboxylic acid

InChi Key: HJGFPNFAFSFDNN-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H12N4O2/c1-2-12-4-3-5-14(8-12)23-19-18-16(10-21-11-22-18)15-7-6-13(20(25)26)9-17(15)24-19/h1,3-11H,(H,23,24)(H,25,26)

SMILES Code: O=C(C1=CC=C2C3=CN=CN=C3C(NC4=CC=CC(C#C)=C4)=NC2=C1)O

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 340.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zanin S, Borgo C, Girardi C, O'Brien SE, Miyata Y, Pinna LA, Donella-Deana A,  Ruzzene M. Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells. PLoS One. 2012;7(11):e49193. doi: 10.1371/journal.pone.0049193. Epub 2012  Nov 8. PubMed PMID: 23145120; PubMed Central PMCID: PMC3493520.



Additional Information