CNX-2006

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406482

CAS#: 1375465-09-0

Description: CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.

Price and Availability

Size	Price	Shipping out time
1g	USD 3450	2 Weeks
2g	USD 4950	2 Weeks
5g	USD 7950	2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-02-24. Prices are subject to change without notice.

CNX-2006, purity > 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406482
Name: CNX-2006
CAS#: 1375465-09-0
Chemical Formula: C26H27F4N7O2
Exact Mass: 545.21624
Molecular Weight: 545.53189
Elemental Analysis: C, 57.24; H, 4.99; F, 13.93; N, 17.97; O, 5.87

Synonym: CNX2006; CNX 2006; CNX-2006.

IUPAC/Chemical Name: N-(3-((2-((4-((1-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

InChi Key: BFSRTTWIPACGMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27F4N7O2/c1-3-23(38)33-16-5-4-6-17(11-16)34-24-20(26(28,29)30)13-31-25(36-24)35-21-8-7-18(12-22(21)39-2)32-19-14-37(15-19)10-9-27/h3-8,11-13,19,32H,1,9-10,14-15H2,2H3,(H,33,38)(H2,31,34,35,36)

SMILES Code: C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(NC4CN(CCF)C4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O

Technical Data

Appearance:

white solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Additional Information

CNX-2006 is a Me-Too version of CO-1686, which structures are compared as below:

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