WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406238
Description: CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.
MedKoo Cat#: 406238
Chemical Formula: C30H32BrClN4O2
Exact Mass: 594.13972
Molecular Weight: 595.96
Elemental Analysis: C, 60.46; H, 5.41; Br, 13.41; Cl, 5.95; N, 9.40; O, 5.37
CK0106023, purity > 98% is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: CK0106023; CK 0106023; CK0106023
IUPAC/Chemical Name: N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
InChi Key: PZVLDHUUSWUATQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H32BrClN4O2/c1-4-27(35(18-8-17-34(2)3)29(37)22-11-13-23(31)14-12-22)28-33-26-19-24(32)15-16-25(26)30(38)36(28)20-21-9-6-5-7-10-21/h5-7,9-16,19,27H,4,8,17-18,20H2,1-3H3
SMILES Code: O=C(N(C(C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC)CCCN(C)C)C4=CC=C(Br)C=C4
The following data is based on the product molecular weight 595.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Jiang C, Chen Y, Wang X, You Q. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly. J Mol Model. 2007 Sep;13(9):987-92. Epub 2007 Jun 23. PubMed PMID: 17588180.
2: Zhang B, Senator D, Wilson CJ, Ng SC. Development of a high-throughput robotic fluorescence-based assay for HsEg5 inhibitor screening. Anal Biochem. 2005 Oct 15;345(2):326-35. PubMed PMID: 16125662.
3: Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. PubMed PMID: 15126370.