WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406238
CAS#: 336115-72-1
Description: CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons.
MedKoo Cat#: 406238
Name: CK0106023
CAS#: 336115-72-1
Chemical Formula: C30H32BrClN4O2
Exact Mass: 594.13972
Molecular Weight: 595.96
Elemental Analysis: C, 60.46; H, 5.41; Br, 13.41; Cl, 5.95; N, 9.40; O, 5.37
This product is not in stock, which may be available by custom synthesis.
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Synonym: CK0106023; CK 0106023; CK0106023
IUPAC/Chemical Name: N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl]-4-bromo-N-[3-(dimethylamino)propyl]benzamide
InChi Key: PZVLDHUUSWUATQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H32BrClN4O2/c1-4-27(35(18-8-17-34(2)3)29(37)22-11-13-23(31)14-12-22)28-33-26-19-24(32)15-16-25(26)30(38)36(28)20-21-9-6-5-7-10-21/h5-7,9-16,19,27H,4,8,17-18,20H2,1-3H3
SMILES Code: O=C(N(C(C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC)CCCN(C)C)C4=CC=C(Br)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 595.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Jiang C, Chen Y, Wang X, You Q. Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly. J Mol Model. 2007 Sep;13(9):987-92. Epub 2007 Jun 23. PubMed PMID: 17588180.
2: Zhang B, Senator D, Wilson CJ, Ng SC. Development of a high-throughput robotic fluorescence-based assay for HsEg5 inhibitor screening. Anal Biochem. 2005 Oct 15;345(2):326-35. PubMed PMID: 16125662.
3: Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. PubMed PMID: 15126370.
