WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406199
CAS#: 500272-80-0
Description: CInQ-03 is a novel and specific MEK inhibitor both in vitro and in vivo.
MedKoo Cat#: 406199
Name: CInQ-03
CAS#: 500272-80-0
Chemical Formula: C22H12ClN5O
Exact Mass: 397.07304
Molecular Weight: 397.82
Elemental Analysis: C, 66.42; H, 3.04; Cl, 8.91; N, 17.60; O, 4.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: CInQ03
IUPAC/Chemical Name: 2-chloro-N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)benzamide
InChi Key: HLFGQICCFZTXTP-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H12ClN5O/c23-16-6-2-1-5-14(16)22(29)25-13-9-10-28-19(11-13)15(12-24)20-21(28)27-18-8-4-3-7-17(18)26-20/h1-11H,(H,25,29)
SMILES Code: O=C(NC1=CC2=C(C#N)C3=NC4=CC=CC=C4N=C3N2C=C1)C5=CC=CC=C5Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 397.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kim DJ, Lee MH, Reddy K, Li Y, Lim DY, Xie H, Lee SY, Yeom YI, Bode AM, Dong Z. CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo. Carcinogenesis. 2013 Feb 14. [Epub ahead of print] PubMed PMID: 23354306.
