WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406100
Description: CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.
MedKoo Cat#: 406100
Chemical Formula: C29H27N5O
Exact Mass: 461.22156
Molecular Weight: 461.55758
Elemental Analysis: C, 75.46; H, 5.90; N, 15.17; O, 3.47
CGI560 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: CGI560; CGI560; CGI 560
IUPAC/Chemical Name: 4-(tert-butyl)-N-(3-(8-(phenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)benzamide
InChi Key: IJMHHZDBRUGXNO-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H27N5O/c1-29(2,3)22-14-12-20(13-15-22)28(35)32-24-11-7-8-21(18-24)25-19-34-17-16-30-27(34)26(33-25)31-23-9-5-4-6-10-23/h4-19H,1-3H3,(H,31,33)(H,32,35)
SMILES Code: O=C(NC1=CC=CC(C2=CN3C(C(NC4=CC=CC=C4)=N2)=NC=C3)=C1)C5=CC=C(C(C)(C)C)C=C5
The following data is based on the product molecular weight 461.55758 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lou Y, Owens TD, Kuglstatter A, Kondru RK, Goldstein DM. Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies. J Med Chem. 2012 May 24;55(10):4539-50. doi: 10.1021/jm300035p. Epub 2012 Mar 21. Review. PubMed PMID: 22394077.