WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 402210
Description: CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent.
MedKoo Cat#: 402210
Chemical Formula: C21H23N7O3S2
Exact Mass: 485.13038
Molecular Weight: 485.58
Elemental Analysis: C, 51.94; H, 4.77; N, 20.19; O, 9.88; S, 13.21
Synonym: CDKI83; CDKI-83; CDKI 83.
IUPAC/Chemical Name: 4-(4-methyl-2-(methylamino)thiazol-5-yl)-2-((4-methyl-3-(morpholinosulfonyl)phenyl)amino)pyrimidine-5-carbonitrile
InChi Key: SSEDQERECATUBR-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H23N7O3S2/c1-13-4-5-16(10-17(13)33(29,30)28-6-8-31-9-7-28)26-20-24-12-15(11-22)18(27-20)19-14(2)25-21(23-3)32-19/h4-5,10,12H,6-9H2,1-3H3,(H,23,25)(H,24,26,27)
SMILES Code: N#CC1=CN=C(NC2=CC=C(C)C(S(=O)(N3CCOCC3)=O)=C2)N=C1C4=C(C)N=C(NC)S4
The following activity data of CDKI-83 was directly copied from Invest New Drugs. 2012 Jun;30(3):889-97:
1: Liu X, Lam F, Shi S, Fischer PM, Wang S. In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83. Invest New Drugs. 2012 Jun;30(3):889-97. doi: 10.1007/s10637-011-9641-5. Epub 2011 Feb 18. PubMed PMID: 21331744.