CBP-93872

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406529

CAS#: 67427-51-4

Description: CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy.


Chemical Structure

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CBP-93872
CAS# 67427-51-4

Theoretical Analysis

MedKoo Cat#: 406529
Name: CBP-93872
CAS#: 67427-51-4
Chemical Formula: C10H15BrN2O
Exact Mass: 258.03678
Molecular Weight: 259.14
Elemental Analysis: C, 46.35; H, 5.83; Br, 30.83; N, 10.81; O, 6.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CBP93872; CBP 93872; CBP-93872.

IUPAC/Chemical Name: 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol

InChi Key: AOFSWDJNINCPJA-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H15BrN2O/c1-7-2-3-10(9(11)4-7)13-6-8(14)5-12/h2-4,8,13-14H,5-6,12H2,1H3

SMILES Code: OC(CNC1=CC=C(C)C=C1Br)CN

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 259.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Cancer Res. 2014 Jul 15;74(14):3880-9. doi: 10.1158/0008-5472.CAN-13-3604. Epub 2014 May 29. PubMed PMID: 24876101.

2: Harada N, Watanabe Y, Yoshimura Y, Sakumoto H, Makishima F, Tsuchiya M, Nakanishi K, Nakanishi M, Aoki Y. Identification of a checkpoint modulator with synthetic lethality to p53 mutants. Anticancer Drugs. 2011 Nov;22(10):986-94. doi: 10.1097/CAD.0b013e328349dd43. PubMed PMID: 21822123.



Additional Information