WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406584
Description: CA-224 is potent CDK4 inhibitor, is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro. CA-224 blocks the growth of cancer cells at G0/ G1 phase of the cell cycle. CA-224 also blocks the cell cycle at G2/M phase, which is explained by the fact that it inhibits tubulin polymerization. Additionally, CA-224 acts as an enhancer of depolymerization for taxol-stabilized tubulin. CA-224 selectively induces apoptosis of SV40 large Tantigen. transformed cells and significantly reduces colony formation efficiency, in a dose-dependent manner, of lung cancer cells. The promising efficacy of CA-224 in human xenograft models as well as its excellent therapeutic window indicates its potential for clinical development.
MedKoo Cat#: 406584
Chemical Formula: C24H22N2O
Exact Mass: 354.1732
Molecular Weight: 354.4443
Elemental Analysis: C, 81.33; H, 6.26; N, 7.90; O, 4.51
CA-224, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: CA224; CA 224; CA-224.
IUPAC/Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-N-methyl-[1,1'-biphenyl]-4-carboxamide
InChi Key: CPKLVRIYXBROSG-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H22N2O/c1-26(16-15-21-17-25-23-10-6-5-9-22(21)23)24(27)20-13-11-19(12-14-20)18-7-3-2-4-8-18/h2-14,17,25H,15-16H2,1H3
SMILES Code: O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N(CCC3=CNC4=C3C=CC=C4)C
The following data is based on the product molecular weight 354.4443 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mahale S, Aubry C, James Wilson A, Jenkins PR, MarÃ©chal JD, Sutcliffe MJ, Chaudhuri B. CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4272-8. Epub 2006 Jun 5. PubMed PMID: 16750360.
2: Webb J. Estimating the potential for ammonia emissions from livestock excreta and manures. Environ Pollut. 2001;111(3):395-406. PubMed PMID: 11202744.