WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401156
Description: BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells.
MedKoo Cat#: 401156
Chemical Formula: C24H25ClN4O
Exact Mass: 420.17169
Molecular Weight: 420.9345
Elemental Analysis: C, 68.48; H, 5.99; Cl, 8.42; N, 13.31; O, 3.80
BRN-103, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: BRN103; BRN103; BRN 103
IUPAC/Chemical Name: 2-((1-benzylpiperidin-4-yl)amino)-N-(3-chlorophenyl)nicotinamide
InChi Key: FJLKVQYKXSXIPA-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H25ClN4O/c25-19-8-4-9-21(16-19)28-24(30)22-10-5-13-26-23(22)27-20-11-14-29(15-12-20)17-18-6-2-1-3-7-18/h1-10,13,16,20H,11-12,14-15,17H2,(H,26,27)(H,28,30)
SMILES Code: O=C(NC1=CC=CC(Cl)=C1)C2=C(NC3CCN(CC4=CC=CC=C4)CC3)N=CC=C2
The following data is based on the product molecular weight 420.9345 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Choi HE, Yoo MS, Choi JH, Lee JY, Kim JH, Kim JH, Lee JK, Kim GI, Park Y, Chi YH, Paik SH, Lee JH, Lee KT. BRN-103, a novel nicotinamide derivative, inhibits VEGF-induced angiogenesis and proliferation in human umbilical vein endothelial cells. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6236-41. doi: 10.1016/j.bmcl.2011.09.022. Epub 2011 Sep 13. PubMed PMID: 21963305.