WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406373
Description: BMS-337197 is a a potent inhibitor of IMPDH with potential anticancer activity.
MedKoo Cat#: 406373
Chemical Formula: C26H27N5O5
Exact Mass: 489.20122
Molecular Weight: 489.52
Elemental Analysis: C, 63.79; H, 5.56; N, 14.31; O, 16.34
Synonym: BMS337197; BMS 337197; BMS-337197.
IUPAC/Chemical Name: N-(2-(2-((3-methoxy-4-(oxazol-5-yl)phenyl)amino)oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide
InChi Key: GLOULEOFVQQCTE-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H27N5O5/c1-30(25(32)16-31-9-11-34-12-10-31)21-6-4-3-5-19(21)24-15-28-26(36-24)29-18-7-8-20(22(13-18)33-2)23-14-27-17-35-23/h3-8,13-15,17H,9-12,16H2,1-2H3,(H,28,29)
SMILES Code: O=C(N(C1=CC=CC=C1C2=CN=C(NC3=CC=C(C4=CN=CO4)C(OC)=C3)O2)C)CN5CCOCC5
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 489.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Beevers RE, Buckley GM, Davies N, Fraser JL, Galvin FC, Hannah DR, Haughan AF, Jenkins K, Mack SR, Pitt WR, Ratcliffe AJ, Richard MD, Sabin V, Sharpe A, Williams SC. Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17. PubMed PMID: 16483769.
2: Dhar TG, Guo J, Shen Z, Pitts WJ, Gu HH, Chen BC, Zhao R, Bednarz MS, Iwanowicz EJ. A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues. Org Lett. 2002 Jun 13;4(12):2091-3. PubMed PMID: 12049525.