WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 401152
CAS#: 582315-72-8
Description: BMS-265246 is a potent CDK1/CDK2 selective inhibitor [(CDK1/cycB IC(50)=6 nM, CDK2/cycE IC(50)=9 nM)].
MedKoo Cat#: 401152
Name: BMS-265246
CAS#: 582315-72-8
Chemical Formula: C18H17F2N3O2
Exact Mass: 345.12888
Molecular Weight: 345.34
Elemental Analysis: C, 62.60; H, 4.96; F, 11.00; N, 12.17; O, 9.27
Synonym: BMS265246; BMS-265246; BMS 265246.
IUPAC/Chemical Name: (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone
InChi Key: SCFMWQIQBVZOQR-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)
SMILES Code: O=C(C1=CN=C(NN=C2)C2=C1OCCCC)C3=C(F)C=C(C)C=C3F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 345.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Misra RN, Xiao Hy, Rawlins DB, Shan W, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR. 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2405-8. PubMed PMID: 12824044.
