WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406417
Description: BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents.
MedKoo Cat#: 406417
Chemical Formula: C21H42N4O3S3
Exact Mass: 494.2419
Molecular Weight: 494.77818
Elemental Analysis: C, 50.98; H, 8.56; N, 11.32; O, 9.70; S, 19.44
BIM-46068, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: BIM46068; BIM 46068; BIM-46068.
IUPAC/Chemical Name: (S)-methyl 2-((R)-3-((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)-5,5-dimethylthiazolidine-4-carboxamido)-4-(methylthio)butanoate
InChi Key: IRLFXGFBZICNNV-IGKNDFSCSA-N
InChi Code: InChI=1S/C21H42N4O3S3/c1-7-14(2)17(23-10-15(22)12-29)11-25-13-31-21(3,4)18(25)19(26)24-16(8-9-30-6)20(27)28-5/h14-18,23,29H,7-13,22H2,1-6H3,(H,24,26)/t14-,15+,16-,17+,18+/m0/s1
SMILES Code: O=C(OC)[C@@H](NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O)CCSC
The following data is based on the product molecular weight 494.77818 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Prevost GP, Pradines A, Viossat I, Brezak MC, Miquel K, Lonchampt MO, Kasprzyk P, Favre G, Pignol B, Le Breton C, Dong J, Morgan B. Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068. Int J Cancer. 1999 Oct 8;83(2):283-7. PubMed PMID: 10471540.