BIM-46068

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406417

CAS#: 201487-53-8

Description: BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents.


Chemical Structure

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BIM-46068
CAS# 201487-53-8

Theoretical Analysis

MedKoo Cat#: 406417
Name: BIM-46068
CAS#: 201487-53-8
Chemical Formula: C21H42N4O3S3
Exact Mass: 494.2419
Molecular Weight: 494.77818
Elemental Analysis: C, 50.98; H, 8.56; N, 11.32; O, 9.70; S, 19.44

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

BIM-46068, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: BIM46068; BIM 46068; BIM-46068.

IUPAC/Chemical Name: (S)-methyl 2-((R)-3-((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)-5,5-dimethylthiazolidine-4-carboxamido)-4-(methylthio)butanoate

InChi Key: IRLFXGFBZICNNV-IGKNDFSCSA-N

InChi Code: InChI=1S/C21H42N4O3S3/c1-7-14(2)17(23-10-15(22)12-29)11-25-13-31-21(3,4)18(25)19(26)24-16(8-9-30-6)20(27)28-5/h14-18,23,29H,7-13,22H2,1-6H3,(H,24,26)/t14-,15+,16-,17+,18+/m0/s1

SMILES Code: O=C(OC)[C@@H](NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O)CCSC

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 494.77818 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Prevost GP, Pradines A, Viossat I, Brezak MC, Miquel K, Lonchampt MO, Kasprzyk P, Favre G, Pignol B, Le Breton C, Dong J, Morgan B. Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068. Int J Cancer. 1999 Oct 8;83(2):283-7. PubMed PMID: 10471540.



Additional Information