WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406307
Description: BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.
MedKoo Cat#: 406307
Chemical Formula: C32H47N7O4
Exact Mass: 593.36895
Molecular Weight: 593.76008
Elemental Analysis: C, 64.73; H, 7.98; N, 16.51; O, 10.78
BI-4834, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: BI4834; BI-4834; BI 4834.
IUPAC/Chemical Name: N-(4-((2R,6S)-2,6-dimethylmorpholino)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide
InChi Key: CJVRBBGCMCITBD-AHXLLTOYSA-N
InChi Code: InChI=1S/C32H47N7O4/c1-8-26-31(41)37(6)27-16-33-32(36-29(27)39(26)19(2)3)35-25-14-9-22(15-28(25)42-7)30(40)34-23-10-12-24(13-11-23)38-17-20(4)43-21(5)18-38/h9,14-16,19-21,23-24,26H,8,10-13,17-18H2,1-7H3,(H,34,40)(H,33,35,36)/t20-,21+,23?,24?,26-/m1/s1
SMILES Code: O=C(NC1CCC(N2C[C@@H](C)O[C@@H](C)C2)CC1)C3=CC=C(NC(N=C4N(C(C)C)[C@@H]5CC)=NC=C4N(C)C5=O)C(OC)=C3
The following data is based on the product molecular weight 593.76008 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. By Grosstessner-Hain, Karin; Hegemann, Bjoern; Novatchkova, Maria; Rameseder, Jonathan; Joughin, Brian A.; Hudecz, Otto; Roitinger, Elisabeth; Pichler, Peter; Kraut, Norbert; Yaffe, Michael B.; et al From Molecular and Cellular Proteomics (2011), 10(11), M111.008540.
BI-4834 is an analogue compound of BI-2536. The chemical structure comparison is the following: