WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406307

CAS#: 876371-13-0

Description: BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.

Chemical Structure

CAS# 876371-13-0

Theoretical Analysis

MedKoo Cat#: 406307
Name: BI-4834
CAS#: 876371-13-0
Chemical Formula: C32H47N7O4
Exact Mass: 593.36895
Molecular Weight: 593.76008
Elemental Analysis: C, 64.73; H, 7.98; N, 16.51; O, 10.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BI4834; BI-4834; BI 4834.

IUPAC/Chemical Name: N-(4-((2R,6S)-2,6-dimethylmorpholino)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide


InChi Code: InChI=1S/C32H47N7O4/c1-8-26-31(41)37(6)27-16-33-32(36-29(27)39(26)19(2)3)35-25-14-9-22(15-28(25)42-7)30(40)34-23-10-12-24(13-11-23)38-17-20(4)43-21(5)18-38/h9,14-16,19-21,23-24,26H,8,10-13,17-18H2,1-7H3,(H,34,40)(H,33,35,36)/t20-,21+,23?,24?,26-/m1/s1

SMILES Code: O=C(NC1CCC(N2C[C@@H](C)O[C@@H](C)C2)CC1)C3=CC=C(NC(N=C4N(C(C)C)[C@@H]5CC)=NC=C4N(C)C5=O)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 593.76008 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. By Grosstessner-Hain, Karin; Hegemann, Bjoern; Novatchkova, Maria; Rameseder, Jonathan; Joughin, Brian A.; Hudecz, Otto; Roitinger, Elisabeth; Pichler, Peter; Kraut, Norbert; Yaffe, Michael B.; et al   From Molecular and Cellular Proteomics (2011), 10(11), M111.008540.

Additional Information

BI-4834 is an analogue compound of BI-2536. The chemical structure comparison is the following: