BI-4834

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406307

CAS#: 876371-13-0

Description: BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.


Price and Availability

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BI-4834, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406307
Name: BI-4834
CAS#: 876371-13-0
Chemical Formula: C32H47N7O4
Exact Mass: 593.36895
Molecular Weight: 593.76008
Elemental Analysis: C, 64.73; H, 7.98; N, 16.51; O, 10.78


Synonym: BI4834; BI-4834; BI 4834.

IUPAC/Chemical Name: N-(4-((2R,6S)-2,6-dimethylmorpholino)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide

InChi Key: CJVRBBGCMCITBD-AHXLLTOYSA-N

InChi Code: InChI=1S/C32H47N7O4/c1-8-26-31(41)37(6)27-16-33-32(36-29(27)39(26)19(2)3)35-25-14-9-22(15-28(25)42-7)30(40)34-23-10-12-24(13-11-23)38-17-20(4)43-21(5)18-38/h9,14-16,19-21,23-24,26H,8,10-13,17-18H2,1-7H3,(H,34,40)(H,33,35,36)/t20-,21+,23?,24?,26-/m1/s1

SMILES Code: O=C(NC1CCC(N2C[C@@H](C)O[C@@H](C)C2)CC1)C3=CC=C(NC(N=C4N(C(C)C)[C@@H]5CC)=NC=C4N(C)C5=O)C(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

BI-4834 is an analogue compound of BI-2536. The chemical structure comparison is the following:
 
 
 


References

1. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. By Grosstessner-Hain, Karin; Hegemann, Bjoern; Novatchkova, Maria; Rameseder, Jonathan; Joughin, Brian A.; Hudecz, Otto; Roitinger, Elisabeth; Pichler, Peter; Kraut, Norbert; Yaffe, Michael B.; et al   From Molecular and Cellular Proteomics (2011), 10(11), M111.008540.