WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406307
Description: BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.
MedKoo Cat#: 406307
Chemical Formula: C32H47N7O4
Exact Mass: 593.36895
Molecular Weight: 593.76008
Elemental Analysis: C, 64.73; H, 7.98; N, 16.51; O, 10.78
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Synonym: BI4834; BI-4834; BI 4834.
IUPAC/Chemical Name: N-(4-((2R,6S)-2,6-dimethylmorpholino)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide
InChi Key: CJVRBBGCMCITBD-AHXLLTOYSA-N
InChi Code: InChI=1S/C32H47N7O4/c1-8-26-31(41)37(6)27-16-33-32(36-29(27)39(26)19(2)3)35-25-14-9-22(15-28(25)42-7)30(40)34-23-10-12-24(13-11-23)38-17-20(4)43-21(5)18-38/h9,14-16,19-21,23-24,26H,8,10-13,17-18H2,1-7H3,(H,34,40)(H,33,35,36)/t20-,21+,23?,24?,26-/m1/s1
SMILES Code: O=C(NC1CCC(N2C[C@@H](C)O[C@@H](C)C2)CC1)C3=CC=C(NC(N=C4N(C(C)C)[C@@H]5CC)=NC=C4N(C)C5=O)C(OC)=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 593.76008 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. By Grosstessner-Hain, Karin; Hegemann, Bjoern; Novatchkova, Maria; Rameseder, Jonathan; Joughin, Brian A.; Hudecz, Otto; Roitinger, Elisabeth; Pichler, Peter; Kraut, Norbert; Yaffe, Michael B.; et al From Molecular and Cellular Proteomics (2011), 10(11), M111.008540.
BI-4834 is an analogue compound of BI-2536. The chemical structure comparison is the following: