AVE-8063

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406505

CAS#: 162705-07-9

Description: AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity.

Chemical Structure

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AVE-8063
CAS# 162705-07-9
Instruction

Theoretical Analysis

MedKoo Cat#: 406505
Name: AVE-8063
CAS#: 162705-07-9
Chemical Formula: C18H21NO4
Exact Mass: 315.15
Molecular Weight: 315.360
Elemental Analysis: C, 68.55; H, 6.71; N, 4.44; O, 20.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: AVE8063; AVE 8063; AVE8063.

IUPAC/Chemical Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)aniline

InChi Key: QSAMWSFELUCKOA-WAYWQWQTSA-N

InChi Code: InChI=1S/C18H21NO4/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11H,19H2,1-4H3/b6-5-

SMILES Code: NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
View handling instruction
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.360000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R. Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds. Bioorg Med Chem. 2009 Sep 1;17(17):6422-31. doi: 10.1016/j.bmc.2009.07.012. Epub 2009 Jul 9. PubMed PMID: 19647439. 2: Liou JP, Chang JY, Chang CW, Chang CY, Mahindroo N, Kuo FM, Hsieh HP. Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. J Med Chem. 2004 May 20;47(11):2897-905. PubMed PMID: 15139768.