AVE-8063

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406505

CAS#: 162705-07-9

Description: AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity.

Price and Availability

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Pricing updated 2020-08-03. Prices are subject to change without notice.

AVE-8063, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406505
Name: AVE-8063
CAS#: 162705-07-9
Chemical Formula: C18H21NO4
Exact Mass: 315.14706
Molecular Weight: 315.36
Elemental Analysis: C, 68.55; H, 6.71; N, 4.44; O, 20.29

Synonym: AVE8063; AVE 8063; AVE8063.

IUPAC/Chemical Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)aniline

InChi Key: QSAMWSFELUCKOA-WAYWQWQTSA-N

InChi Code: InChI=1S/C18H21NO4/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11H,19H2,1-4H3/b6-5-

SMILES Code: NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

Technical Data

Appearance:

white solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Additional Information

References

1: Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R. Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds. Bioorg Med Chem. 2009 Sep 1;17(17):6422-31. doi: 10.1016/j.bmc.2009.07.012. Epub 2009 Jul 9. PubMed PMID: 19647439.

2: Liou JP, Chang JY, Chang CW, Chang CY, Mahindroo N, Kuo FM, Hsieh HP. Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. J Med Chem. 2004 May 20;47(11):2897-905. PubMed PMID: 15139768.

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