WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406505
Description: AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity.
MedKoo Cat#: 406505
Chemical Formula: C18H21NO4
Exact Mass: 315.14706
Molecular Weight: 315.36
Elemental Analysis: C, 68.55; H, 6.71; N, 4.44; O, 20.29
AVE-8063, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: AVE8063; AVE 8063; AVE8063.
IUPAC/Chemical Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)aniline
InChi Key: QSAMWSFELUCKOA-WAYWQWQTSA-N
InChi Code: InChI=1S/C18H21NO4/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11H,19H2,1-4H3/b6-5-
SMILES Code: NC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
The following data is based on the product molecular weight 315.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R. Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds. Bioorg Med Chem. 2009 Sep 1;17(17):6422-31. doi: 10.1016/j.bmc.2009.07.012. Epub 2009 Jul 9. PubMed PMID: 19647439.
2: Liou JP, Chang JY, Chang CW, Chang CY, Mahindroo N, Kuo FM, Hsieh HP. Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents. J Med Chem. 2004 May 20;47(11):2897-905. PubMed PMID: 15139768.