AMP423

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 401025

CAS#: 219501-57-2

Description: AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive.


Chemical Structure

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AMP423
CAS# 219501-57-2

Theoretical Analysis

MedKoo Cat#: 401025
Name: AMP423
CAS#: 219501-57-2
Chemical Formula: C14H11N3O
Exact Mass: 237.0902
Molecular Weight: 237.262
Elemental Analysis: C, 70.87; H, 4.67; N, 17.71; O, 6.74

Size Price Shipping out time Quantity
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Pricing updated 2021-02-26. Prices are subject to change without notice.

AMP423, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: AMP423; AMP-423; AMP 423.

IUPAC/Chemical Name: 2-Cyano-N-1-naphthalenyl-1-aziridinecarboxamide

InChi Key: WTPBNYGXGYMXNL-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11N3O/c15-8-11-9-17(11)14(18)16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11H,9H2,(H,16,18)

SMILES Code: O=C(N1C(C#N)C1)NC2=C3C=CC=CC3=CC=C2

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 237.262 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Dorr RT, Wisner L, Samulitis BK, Landowski TH, Remers WA. Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423. Cancer Chemother Pharmacol. 2012 Apr;69(4):1039-49. doi: 10.1007/s00280-011-1784-8. Epub 2011 Dec 21. PubMed PMID: 22186884; PubMed Central PMCID: PMC3314130.



Additional Information