WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406209
CAS#: 146535-11-7
Description: AG1296 is a potent and specific inhibitor of the platelet-derived growth factor (PDGF) receptor tyrosine kinase.
MedKoo Cat#: 406209
Name: AG1296
CAS#: 146535-11-7
Chemical Formula: C16H14N2O2
Exact Mass: 266.10553
Molecular Weight: 266.29
Elemental Analysis: C, 72.16; H, 5.30; N, 10.52; O, 12.02
AG1296, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AG1296; AG-1296; AG 1296; tyrphostin AG1296.
IUPAC/Chemical Name: 2-Phenyl-6,7-dimethoxyquinoxaline ; 6,7-Dimethoxy-2-phenylquinoxaline
InChi Key: QNOXYUNHIGOWNY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
SMILES Code: COC1=C(OC)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
The following data is based on the product molecular weight 266.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Watanabe T, Ohtani T, Aihara M, Ishiuchi S. Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models. J Neurosurg. 2013 Jan 11. [Epub ahead of print] PubMed PMID: 23311938.
2: Torres LA, Barbarroja N, Dorado G, Velasco F, López-Pedrera C. VEGF/KDR loop is a target of AG1296 in acute myeloid leukaemia showing FLT3-internal tandem duplications. Br J Haematol. 2009 Jun;145(6):836-8. doi: 10.1111/j.1365-2141.2009.07673.x. Epub 2009 Apr 8. PubMed PMID: 19388942.
3: Ueda S, Ikeda H, Mizuki M, Ishiko J, Matsumura I, Tanaka H, Shibayama H, Sugahara H, Takai E, Zhang X, Machii T, Kanakura Y. Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296. Int J Hematol. 2002 Dec;76(5):427-35. PubMed PMID: 12512837.
4: Kovalenko M, Rönnstrand L, Heldin CH, Loubtchenkov M, Gazit A, Levitzki A, Böhmer FD. Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry. 1997 May 27;36(21):6260-9. PubMed PMID: 9174341.
