WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406210
CAS#: 71897-07-9
Description: AG1295 is a PDGF receptor specific inhibitor. AG1295 exerts a marked inhibitory effect on the activation, migration, and proliferation of porcine and human smooth muscle cells SMCs in vitro and an approximately 50% inhibitory effect on neointimal formation after balloon injury in porcine femoral arteries when delivered via biodegradable nanoparticles. Further studies appear to be warranted to evaluate the applicability of this novel approach to the interventional setting.
MedKoo Cat#: 406210
Name: AG1295
CAS#: 71897-07-9
Chemical Formula: C16H14N2
Exact Mass: 234.1157
Molecular Weight: 234.3
Elemental Analysis: C, 82.02; H, 6.02; N, 11.96
AG1295, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: AG1295; AG-1295; AG 1295; NSC 380341; Tyrphostin AG 1295.
IUPAC/Chemical Name: 6,7-dimethyl-2-phenylquinoxaline
InChi Key: FQNCLVJEQCJWSU-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
SMILES Code: CC1=C(C)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
The following data is based on the product molecular weight 234.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zheng Y, Ikuno Y, Ohj M, Kusaka S, Jiang R, Cekiç O, Sawa M, Tano Y. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65. PubMed PMID: 12738549.
2: Iwamoto H, Nakamuta M, Tada S, Sugimoto R, Enjoji M, Nawata H. Platelet-derived growth factor receptor tyrosine kinase inhibitor AG1295 attenuates rat hepatic stellate cell growth. J Lab Clin Med. 2000 May;135(5):406-12. PubMed PMID: 10811056.
3: Ludewig D, Kosmehl H, Sommer M, Böhmer FD, Stein G. PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction. Cell Tissue Res. 2000 Jan;299(1):97-103. PubMed PMID: 10654073.
4: Banai S, Wolf Y, Golomb G, Pearle A, Waltenberger J, Fishbein I, Schneider A, Gazit A, Perez L, Huber R, Lazarovichi G, Rabinovich L, Levitzki A, Gertz SD. PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation. 1998 May 19;97(19):1960-9. PubMed PMID: 9609090.
