WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406312
CAS#: 750575-23-6
Description: AG-024104 is a broad spectrum cyclin-dependent kinase inhibitors with potential anticancer activity.
MedKoo Cat#: 406312
Name: AG-024104
CAS#: 750575-23-6
Chemical Formula: C24H28F2N6O4S2
Exact Mass: 566.15815
Molecular Weight: 566.64
Elemental Analysis: C, 50.87; H, 4.98; F, 6.71; N, 14.83; O, 11.29; S, 11.32
AG-024104, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: AG024104; AG 024104; AG-024104
IUPAC/Chemical Name: (4-amino-2-((1-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)sulfonyl)piperidin-4-yl)amino)thiazol-5-yl)(2,6-difluorophenyl)methanone
InChi Key: OBHOHFUFLKWHSB-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H28F2N6O4S2/c1-31(2)12-13-36-19-7-6-16(14-28-19)38(34,35)32-10-8-15(9-11-32)29-24-30-23(27)22(37-24)21(33)20-17(25)4-3-5-18(20)26/h3-7,14-15H,8-13,27H2,1-2H3,(H,29,30)
SMILES Code: O=C(C1=C(N)N=C(NC2CCN(S(=O)(C3=CC=C(OCCN(C)C)N=C3)=O)CC2)S1)C4=C(F)C=CC=C4F
The following data is based on the product molecular weight 566.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Jessen, Bart A.; Lee, Leo; Koudriakova, Tatiana; Haines, Morgan; Lundgren, Karen; Price, Sharon; Nonomiya, Jim; Lewis, Cristina; Stevens, Gregory J. Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors. Journal of Applied Toxicology (2007), 27(2), 133-142
2. Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley K. M.; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried H.; Romines, William H.; Wallace, Michael B.; Yang, Yi. Preparation of thiazolylamino benzamide derivatives as modulators of cell proliferation and inhibitors of protein kinases. PCT Int. Appl. (2003), WO 2003004467 A2 20030116.