WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406311
CAS#: 486414-16-8
Description: AG-012917 is a broad spectrum cyclin-dependent kinase inhibitors with potential anticancer activity.
MedKoo Cat#: 406311
Name: AG-012917
CAS#: 486414-16-8
Chemical Formula: C23H23F2N5O2S
Exact Mass: 471.15405
Molecular Weight: 471.52
Elemental Analysis: C, 58.59; H, 4.92; F, 8.06; N, 14.85; O, 6.79; S, 6.80
This product is not in stock, which may be available by custom synthesis.
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Synonym: AG012917; AG 012917; AG-012917.
IUPAC/Chemical Name: (S)-4-((4-amino-5-(2,6-difluorobenzoyl)thiazol-2-yl)amino)-N-((1-methylpyrrolidin-2-yl)methyl)benzamide
InChi Key: JHOYXMSKUJRBCS-HNNXBMFYSA-N
InChi Code: InChI=1S/C23H23F2N5O2S/c1-30-11-3-4-15(30)12-27-22(32)13-7-9-14(10-8-13)28-23-29-21(26)20(33-23)19(31)18-16(24)5-2-6-17(18)25/h2,5-10,15H,3-4,11-12,26H2,1H3,(H,27,32)(H,28,29)/t15-/m0/s1
SMILES Code: O=C(NC[C@H]1N(C)CCC1)C2=CC=C(NC3=NC(N)=C(C(C4=C(F)C=CC=C4F)=O)S3)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition: 0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly.
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 471.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Jessen, Bart A.; Lee, Leo; Koudriakova, Tatiana; Haines, Morgan; Lundgren, Karen; Price, Sharon; Nonomiya, Jim; Lewis, Cristina; Stevens, Gregory J. Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors. Journal of Applied Toxicology (2007), 27(2), 133-142
2. Chu, Shao Song; Alegria, Larry Andrew; Bleckman, Ted Michael; Chong, Wesley K. M.; Duvadie, Rohit K.; Li, Lin; Reich, Siegfried H.; Romines, William H.; Wallace, Michael B.; Yang, Yi. Preparation of thiazolylamino benzamide derivatives as modulators of cell proliferation and inhibitors of protein kinases. PCT Int. Appl. (2003), WO 2003004467 A2 20030116.
