WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406215
CAS#: 228400-22-4
Description: AFG210 is a novel first-generation “type II” FLT3 inhibitor.
MedKoo Cat#: 406215
Name: AFG210
CAS#: 228400-22-4
Chemical Formula: C19H14F3N3O2
Exact Mass: 373.10381
Molecular Weight: 373.33
Elemental Analysis: C, 61.13; H, 3.78; F, 15.27; N, 11.26; O, 8.57
AFG210, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: AFG-210; AFG 210; AFG210.
IUPAC/Chemical Name: 1-(4-(pyridin-4-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChi Key: DDDLGNOZDKDSEG-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H14F3N3O2/c20-19(21,22)13-2-1-3-15(12-13)25-18(26)24-14-4-6-16(7-5-14)27-17-8-10-23-11-9-17/h1-12H,(H2,24,25,26)
SMILES Code: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=NC=C3)C=C2
The following data is based on the product molecular weight 373.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Weisberg E, Roesel J, Furet P, Bold G, Imbach P, Flörsheimer A, Caravatti G, Jiang J, Manley P, Ray A, Griffin JD. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. doi: 10.1177/1947601910396505. PubMed PMID: 21779428; PubMed Central PMCID: PMC3092267.