WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406214
CAS#: 630122-37-1
Description: AFG206 is the novel first-generation "type II" FLT3 inhibitor.
MedKoo Cat#: 406214
Name: AFG206
CAS#: 630122-37-1
Chemical Formula: C20H19N3O2
Exact Mass: 333.14773
Molecular Weight: 333.38
Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60
This product is not in stock, which may be available by custom synthesis.
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Synonym: AFG206; AFG 206; AFG-206.
IUPAC/Chemical Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea
InChi Key: UUJSPHQATNSVLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H19N3O2/c1-2-15-3-5-16(6-4-15)22-20(24)23-17-7-9-18(10-8-17)25-19-11-13-21-14-12-19/h3-14H,2H2,1H3,(H2,22,23,24)
SMILES Code: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=C(CC)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 333.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Ellen Weisberg, Johannes Roesel, Pascal Furet, Guido Bold, Patricia Imbach, Andreas Flörsheimer, Georgio Caravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October; 1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267
