WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406214
Description: AFG206 is the novel first-generation "type II" FLT3 inhibitor.
MedKoo Cat#: 406214
Chemical Formula: C20H19N3O2
Exact Mass: 333.14773
Molecular Weight: 333.38
Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60
AFG206, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: AFG206; AFG 206; AFG-206.
IUPAC/Chemical Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea
InChi Key: UUJSPHQATNSVLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H19N3O2/c1-2-15-3-5-16(6-4-15)22-20(24)23-17-7-9-18(10-8-17)25-19-11-13-21-14-12-19/h3-14H,2H2,1H3,(H2,22,23,24)
SMILES Code: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=C(CC)C=C3
The following data is based on the product molecular weight 333.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ellen Weisberg, Johannes Roesel, Pascal Furet, Guido Bold, Patricia Imbach, Andreas FlÃ¶rsheimer, Georgio Caravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October; 1(10): 1021Â–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267