AFG206

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406214

CAS#: 630122-37-1

Description: AFG206 is the novel first-generation "type II" FLT3 inhibitor.

Chemical Structure

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AFG206
CAS# 630122-37-1
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 406214
Name: AFG206
CAS#: 630122-37-1
Chemical Formula: C20H19N3O2
Exact Mass: 333.14773
Molecular Weight: 333.38
Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60

Size Price Shipping out time Quantity
Inquire bulk and customized quantity
Pricing updated 2021-03-03. Prices are subject to change without notice.

AFG206, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: AFG206; AFG 206; AFG-206.

IUPAC/Chemical Name: 1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea

InChi Key: UUJSPHQATNSVLQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19N3O2/c1-2-15-3-5-16(6-4-15)22-20(24)23-17-7-9-18(10-8-17)25-19-11-13-21-14-12-19/h3-14H,2H2,1H3,(H2,22,23,24)

SMILES Code: O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=C(CC)C=C3

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 333.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1:  Ellen Weisberg, Johannes Roesel, Pascal Furet, Guido Bold, Patricia Imbach, Andreas Flörsheimer, Georgio Caravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October; 1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267

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AFG206



Additional Information